Periodontitis: a polymicrobial disruption of host homeostasis

By R. Darveau. Nature Reviews Microbiology, 2010

1,647 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/402df9feea5d2e0896ed6de3426ce4cb03885803

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In Periodontics

In Physiology

G. Hajishengallis

Citations in the corpus

Polymicrobial Interactions: Impact on Pathogenesis and Human Disease (2012, background): “The difference between the onsets of chronic and localized aggressive forms of periodontitis is unclear at this time but is thought to result from a host genetic predisposition to colonization, a hyperaggressive immune response to oral bacteria involving increased levels of polymorphonuclear infiltr”
Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues (2019, background): “In subgingival biofilms, anaerobic gram-negative species with their biologically active lipopolysaccharide (LPS)-containing cell wall structure may be essential in awakening the inflammatory reaction in the gingiva and culprits of periodontal destruction to occur in periodontitis-susceptible individ”
Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology (2012, neutral): “For instance, P. gingivalis expresses an atypical lipopolysaccharide with a 4-acyl monophosphorylated lipid A moiety that can potently antagonize Toll-like receptor 4, unlike the highly proinflammatory lipopolysaccharides of most other gram-negative bacteria (Coats et al., 2009; Darveau, 2010).”
A Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and the Complement Pathway (2011, background): “…bone loss in young mice under a controlled inflammatory state: a state which also characterizes clinically healthy human periodontal tissue (Darveau, 2010) and is analogous to the evier Inc. immunoinflammatory surveillance state described for the healthy intestine (Hooper and Macpherson,…”
Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study (2016, background): “Because oral health is closely tied to oral microbial status, 16 we hypothesise that the oral health — pancreatic cancer association may have an underlying microbial basis, yet no studies have directly evaluated the relationship between the oral microbiome and subsequent risk for pancreatic cancer.”