HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

By U. Pandey, Zhiping Nie, Y. Batlevi, Brett A. McCray, G. P. Ritson, Natalia B. Nedelsky, S. Schwartz, N. Diprospero, M. A. Knight, Oren Schuldiner and 8 more. Nature, 2007

1,264 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/828537633db009a4fdfb7ee4aa8e56dd6de5df61

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Beth Levine
2. D. Klionsky
3. I. Slaninová
4. Guido Kroemer
5. N. Mizushima
6. V. Deretic
7. Alec C. Kimmelman
8. D. Rubinsztein

In Genetics

1. Beth Levine
2. C. López‐Otín
3. P. Bonaldo
4. D. Cleveland
5. Guido Kroemer
6. D. Klionsky
7. E. Seto
8. G. Hotamisligil

In Molecular Biology

1. Guido Kroemer
2. Beth Levine
3. D. Klionsky
4. I. Slaninová
5. D. Tang
6. R. Kang
7. Guillermo Mariño
8. Eric H. Baehrecke

Citations in the corpus

• HDACs and HDAC Inhibitors in Cancer Development and Therapy (2016, positive): “When the UPS is impaired, autophagy is strongly activated and acts as a compensatory degradation system in an HDAC6-dependent manner (Pandey et al. 2007).”
• A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy (2008, background): “In addition, in Drosophila, a recent study has linked the activity of another deacetylase, HDAC6, to autophagy (28).”
• Autophagy in the pathogenesis of disease. (2008, positive): “Autophagy induced by overexpression of histone deacetylase 6 also compensates for impairment in the ubiquitin-proteasome system in a fly model of spinobulbar muscle dystrophy (Pandey et al., 2007).”
• Ubiquitination and selective autophagy (2012, background): “A molecular link between these systems could be HDAC6, a microtubule-associated deacetylase that interacts with polyubiquitinated proteins and can rescue defects of the UPS by increasing autophagy.(24) Moreover, long-term inhibition of autophagy can increases proteasomal substrates level by compromi”
• Regulation Mechanisms and Signaling Pathways of Autophagy (2009, background): “In addition, microtubules, the tubulin deacetylase HDAC6, and the microtubule motor protein dynein are required for the autophagic clearance of various aggregate-prone proteins in flies and mammalian cells (50,109,117).”
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “Some proteins, such as histone deacetylase-6 (HDAC-6) (30), p53 (31), and p62/SQSTM1 (29), play roles in the cross-talk between the UPS and autophagy.”
• TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. (2010, background): “HDAC6 promotes the aggregation of polyubiquitinated proteins (252,253) and their autophagic degradation (254,255).”