The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity

By Je-in Youn, Dmitry I. Gabrilovich. European Journal of Immunology, 2010

606 citations recorded by the source corpus.

Myeloid‐derived suppressor cells (MDSC) play an important role in the cellular network regulating immune responses in cancer, chronic infectious diseases, autoimmunity, and in other pathological conditions. Morphological, phenotypic and functional heterogeneity is a hallmark of MDSC. This heterogeneity demonstrates the plasticity of this immune suppressive myeloid compartment, and shows how various tumors and infectious agents can have similar biological effects on myeloid cells despite the differences in the factors that they produce to influence the immune system; however, such a heterogeneity creates ambiguity in the definition of MDSC as well as confusion regarding the origin and fate of these cells. In this review, we will discuss recent findings that help to better clarify these issues and to determine the place of MDSC within the myeloid cell lineage.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/8266e2012adbf8b20c893cbc5f3c5136e82a179e

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In Immunology

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Citations in the corpus

• Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis (2012, background): “In murine models of solid tumors and a variety of human cancers, an increase in myeloid cells is observed (4, 5).”
• Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “In analogy to monocyte subsets, those suppressive neutrophilic cells have been termed granulocytic/neutrophilic MDSCs [110].”
• The tumor microenvironment at a glance (2012, background): “A number of studies reported that NK cells in the tumor stroma have an anergic phenotype that is induced by malignant cell-derived transforming growth factor beta (TGF-b) (Fridman et al., 2012).”
• CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma (2016, neutral): “MDSCs are immature bone marrow cells typified by the expression of CD11b, Gr1, and Ly6G/Ly6C (Youn and Gabrilovich, 2010).”