Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

By M. Demers, D. Krause, Daphne Schatzberg, K. Martinod, Jaymie R. Voorhees, T. Fuchs, D. Scadden, D. Wagner. Proceedings of the National Academy of Sciences of the United States of America, 2012

836 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/1343a7ff934bbfcd67bb512ea33b5be27f9c64d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. A. Mócsai
2. M. Egeblad
3. E. Nakasone

In Immunology

1. D. Wagner
2. A. Mócsai
3. K. Martinod
4. M. Egeblad
5. E. Nakasone

Citations in the corpus

• Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016, background): “G-CSF can prime neutrophils for NET formation and is secreted by 4T1 cells (23).”
• Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “The role of CCR5 in neutrophil activation also raises questions, as this receptor is not expressed on neutrophils at high levels (although increased expression was shown upon apoptosis and at the site of inflammation; Ariel et al., 2006; Hartl et al., 2008).”
• Regulated cell death (RCD) in cancer: key pathways and targeted therapies (2022, background): “Overexpression of G-CSF in tumors can increase the number of neutrophils in the blood, produce ROS and cause the formation of nets.(406) Pancreatic cancer (PACA) cells can directly or indirectly induce the formation of nets.”
• Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation (2015, neutral): “Cells were identified as H3Cit + or as spread NETs based on nuclear morphology by Hoechst 33342 stain as previously described 32 .”
• Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. (2013, neutral): “Both DNAse and inhibition of NE have been shown to abrogate NET formation both in vitro and in vivo (48, 53, 59, 61–63).”
• Thrombosis: tangled up in NETs. (2014, methodology): “The elevated DNA and propensity of neutrophils to throw NETs provides a new explanation for cancer-associated thrombosis, as mice with high levels of NET biomarkers, such as plasma H3Cit, show spontaneous thrombosis (Figure 3C).(71)”
• Neutrophil extracellular traps in COVID-19. (2020, neutral): “(20, 34), IL-8 (35, 36), granulocyte colony-stimulating factor (37, 38), and likely others (18).”