The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.

By B. Neel, Haihua Gu, L. Pao. TIBS -Trends in Biochemical Sciences. Regular ed, 2003

1,252 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/823fffc3afe64cdc15db51f085ccf917389dec66

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Karin
2. T. Lawrence
3. V. Nizet
4. James L. Riley
5. N. Perkins
6. S. Ghosh
7. R. Medzhitov
8. A. Mantovani

In Molecular Biology

1. M. Karin
2. T. Lawrence
3. M. McKay
4. DK Morrison
5. Anica M Wandler
6. Crystal M. Botham
7. K. Guillemin
8. R. Medzhitov

Citations in the corpus

• PD-1 signaling in primary T cells (2009, background): “SHP-1 and SHP-2 are structurally related protein tyrosine phosphatases (PTPs) that each contain two N-terminal SH2 domains, a classic PTP domain and a C-terminal tail that harbor sites for tyrosine phosphorylation (49, 50).”
• Spacing Effect: SHP2 Phosphatase Regulates Resting Intervals Between Learning Trials in Long-Term Memory Induction (2009, neutral): “CSW is a key signaling relay in pathways in C. elegans, Drosophila, Xenopus, and mammals (for review, see Neel et al., 2003 ).”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “PI3K signaling is inhibited by the PTEN phosphatase that belongs to the protein tyrosine phosphatase (PTP) family; some of its other members, for instance SHIP, SHP1/2, and CD45, are responsible for negative regulation of TK signaling (Neel et al., 2003).”
• Integrating signals from RTKs to ERK/MAPK (2007, background): “Shp-2 has long been known to be a positive regulator of RTK-mediated Ras activation and is a component of many activated RTK complexes, binding to either the receptor or an associated docking protein (Neel et al., 2003).”
• A Transgenic Drosophila Model Demonstrates That the Helicobacter pylori CagA Protein Functions as a Eukaryotic Gab Adaptor (2008, background): “cell growth, differentiation and survival (reviewed in [4]).”
• Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia (2005, neutral): “DH p185 (1-426) p210 (1-902–927) p230 (1–1,176) Y177 Myr GAG BCR F G 1a 1b”