Is meconium from healthy newborns actually sterile?

By E. Jiménez, M. Marín, Rocío Martín, J. M. Odriozola, M. Olivares, J. Xaus, L. Fernández, J. M. Rodríguez. Research in Microbiology, 2008

926 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/8207fc42a632f4140f50474fbd16a42d3a08ffc4

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Citations in the corpus

The role of microbiome in central nervous system disorders (2013, positive): “However, the presence of bacteria has been detected in the meconium from healthy neonates, which might hint the existence of prenatal mother-to-child transfer of microbiota (Jimenez et al., 2008; Valles et al., 2012).”
Intestinal microbiota in human health and disease: the impact of probiotics (2011, background): “In addition, the isolation of bacteria from the meconium (the first stool of the neonate), umbilical cord blood and amniotic fluid of healthy neonates has been reported (Jiménez et al. 2005, 2008).”
The composition of the gut microbiota throughout life, with an emphasis on early life (2015, background): “To test whether maternal gut bacteria can be transferred to fetuses in utero, two pioneer studies investigated if oral administration of a genetically labeled Enterococcus faecium to pregnant mice resulted in its presence in amniotic fluid and meconium of term offspring after sterile cesarean sectio”
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “These data are further corroborated by the isolation of viable bacteria in the first meconium belonging to the same or similar species previously isolated from umbilical cord blood (198).”
Maturation of the Infant Microbiome Community Structure and Function Across Multiple Body Sites and in Relation to Mode of Delivery (2017, neutral): “…with the placenta and amniotic fluid of preterm and healthy, term pregnancies 37,39,53–55 while work in murine models have demonstrated maternal transmission of bacteria to the fetal gut during gestation, consistent with microbial colonization of the mouse fetus occurring prior to delivery 56 .”
Factors affecting the composition of the gut microbiota, and its modulation (2019, background): “…pregnant mice have demonstrated that oral administration of labeled Enterococcus fecium resulted staring isolated it from the newborn stool samples (Jiménez et al., 2008), this result agree with the evidence maternal microbes can be transferred to the amniotic fluid (Collado et al., 2016;…”
Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes (2015, background): “, genetically labeled [113,114]) microbes in adult organs should appear in the respective organs of their offspring at a similar age more often than their offsprings’ peers.”
Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances (2016, background): “…gut microbes can be transmitted to the offspring (Vaishampayan et al., 2010), with several lines of evidence indicating that such transfer actually starts before birth (Jimenez et al., 2005, 2008; Steel et al., 2005; DiGiulio et al., 2008; Gosalbes et al., 2013, 2015; Aagaard et al., 2014).”
Intestinal barrier and gut microbiota: Shaping our immune responses throughout life (2017, background): “It is proposed that horizontal transfer of bacterial DNA from mother to fetus occurs via the placenta s bloodstream, as Jim enez et al.(64,65) showed by detecting Enterococcus faecium in umbilical cord blood and the meconium in mice previously orally inoculated with the bacteria.”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “…via contamination by maternal vaginal and fecal bacteria (Mackie et al. 1999), there are now data that indicate that term fetuses are not completely sterile and that a prenatal mother-to-child efflux of commensal bacteria occurs (Moles et al. 2013; Satokari et al. 2009; Jiménez et al. 2008).”
A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome (2017, methodology): “Reports employing these techniques propose that bacteria are not only present within the fetal environment in healthy full-term pregnancies [8, 9, 37, 38], but that they also constitute a placental microbiome that jump-starts the colonization of the fetus [8–10] as part of its normal developmental p”