A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

By Shao-Jun Tang, G. Reis, Hyejin Kang, A. Gingras, Nahum Sonenberg, E. Schuman. Proceedings of the National Academy of Sciences of the United States of America, 2001

754 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/815dceeeea672e9012e1dbc8ac64c3060918396f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. C. Hoogenraad
2. Nahum Sonenberg
3. C. Bramham
4. C. Duarte
5. Graciano Leal
6. Diogo Comprido
7. R. J. Kelleher
8. Mauro Costa-Mattioli

In Materials Chemistry

1. C. Hoogenraad
2. M. Sheng

In Molecular Biology

1. Mauro Costa-Mattioli
2. E. Klann
3. C. Bramham
4. Wayne S. Sossin
5. Nahum Sonenberg
6. R. J. Kelleher
7. N. Hay
8. C. Hoogenraad

Citations in the corpus

• Upstream and downstream of mTOR. (2004, background): “Consistent with a requirement for a rapamycin-sensitive signaling pathway in hippocampal synaptic plasticity, mTOR and its downstream targets, 4E-BPs and S6K, are present at post-synaptic sites (Tang et al. 2002).”
• Control of Dendritic Arborization by the Phosphoinositide-3′-Kinase–Akt–Mammalian Target of Rapamycin Pathway (2005, background): “…tract) mRNAs, respectively (Beretta et al., 1996; Jefferies et al., 1997). mTOR and its substrates 4E-BP1 and p70S6K are present in dendrites (Tang et al., 2002), and phosphorylated p70S6K accumulates in dendrites in response to synaptic activity in a rapamycin-sensitive manner (Cammalleri…”
• Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways (2005, background): “…target of rapamycin (mTOR), a serine-threonine kinase, has found a special place in coupling of growth stimuli with cell hypertrophy (Kwon et al., 2003) and, more recently, in the regulation of synaptic plasticity and memory formation (Tang et al., 2002; Cammalleri et al., 2003; Si et al., 2003).”
• BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. (2005, background): “Importantly, the immunosuppressant drug rapamycin, which inhibits mTOR, blocks both late LTP and BDNF-LTP at CA3–CA1 synapses (Cammalleri et al., 2003; Tang et al., 2002).”
• Pten regulates neuronal arborization and social interaction in mice. (2006, positive): “Components of the mTOR/S6K pathway , downstream of PI3K/Akt, are present in synapses and mediate synaptic plasticity through local protein synthesis (Tang et al., 2002).”
• The autistic neuron: troubled translation? (2008, background): “Inhibition of mTORC1 activity in hippocampal neurons attenuates synaptic activity-induced translation, 4E-BP phosphorylation, L-LTP, and BDNF-induced LTP (Tang et al., 2002; Kelleher et al., 2004a).”
• BDNF-induced local protein synthesis and synaptic plasticity. (2014, positive): “(Tang et al., 2002), two forms of plasticity that require protein synthesis.”
• Translational control of long-lasting synaptic plasticity and memory. (2009, positive): “Rapamycin blocks both long-lasting synaptic changes and memory consolidation in mammals in a number of behavioral tasks (Dash et al., 2006; Tang et al., 2002; Tischmeyer et al., 2003), as well as long-term changes in plasticity in Aplysia (Casadio et al., 1999; Hu et al., 2006).”