Associations of subclinical cardiovascular disease with frailty.

By Anne B. Newman, J. Gottdiener, M. McBurnie, C. Hirsch, W. Kop, R. Tracy, J. Walston, L. Fried. The journals of gerontology. Series A, Biological sciences and medical sciences, 2001

793 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/814fdadf35186aafaca1780fee24d9f2d8d68918

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

M. Mack

In Geriatrics and Gerontology

In Physiology

Citations in the corpus

Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures. (2007, background): “Frailty has been linked to declines in circulating levels of gonadal hormones, 25-hydroxyvitamin D, growth hormone, and insulin-like growth factor-1 (IGF-1) (25–27); elevations in pro-inflammatory cytokines and coagulation factors (26,28– 30); subclinical anemia (31); renal insufficiency (32); ather”
Frailty: an emerging research and clinical paradigm--issues and controversies. (2006, background): “Frailty occurring among persons without known chronic disease might be explained by the presence of either subclinical or undiagnosed disease (or conditions) (28).”
Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older. (2005, background): “In fact, preclinical alterations of gait have already been described as sign of subclinical diseases or frailty process (28,29).”
Frailty syndrome: an overview (2014, positive): “As frailty involves multisystem physiologic dysregulation, it is conceivable that chronic inflammation contributes to frailty through its detrimental effects on other physiologic organ systems, such as musculoskeletal and endocrine systems (see following), anemia, clinical and subclinical cardiovasc”
Aging, frailty and age-related diseases (2010, background): “Studies show that comorbidities like congestive heart failure, myocardial infarction, rheumatoid arthritis, peripheral vascular diseases, diabetes and hypertension increase the risk for frailty (Klein et al. 2005; Newman et al. 2001).”
The Burden of Cardiovascular Disease in the Elderly: Morbidity, Mortality, and Costs (2009, background): “Further, there is a growing body of evidence linking CVD with frailty, a clinical syndrome associated with marked loss of physiologic reserve and an increased risk for disability, institutionalization, and death.(37) In CHS, for example, compared to people 65 years old or older with a normal ABI (ie”
A SIMPLE FRAILTY QUESTIONNAIRE (FRAIL) PREDICTS OUTCOMES IN MIDDLE AGED AFRICAN AMERICANS (2012, methodology): “This questionnaire contains 4 questions directed at components of the Cardiovascular Health Study Frailty Index and one (number of illnesses) at the Rockwood Scale (11, 12).”
Inflammation and frailty in the elderly: A systematic review and meta-analysis. (2016, background): “A direct association etween frailty and elevated levels of inflammation, as marked by levated interleukin-6 (IL-6), C-reactive protein (CRP), fibrinogen, nd factor VIII, independent of common chronic disease states has een observed (Newman et al., 2001).”
Frailty: Emergence and Consequences in Women Aged 65 and Older in the Women's Health Initiative Observational Study (2005, methodology): “A frailty cutpoint of 3 or more was used, as in previous studies.(1,11) Other Variables”
Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. (2002, background): “Several questions remain to be explored: What mechanism(s) trigger frailty and its physiological correlates in a subset of older adults? Which of the biochemical changes identified herein play important mechanistic roles? Would interventions targeted at these pathways decrease the risk of being frai”
Frailty Assessment in the Cardiovascular Care of Older Adults (2013, background): “brain infarcts on magnetic resonance imaging, abnormal ankle-brachial index, carotid stenosis, pre-hypertension, and left ventricular hypertrophy (44).”
Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. (2004, background): “Early data from the Cardiovascular Health Study also suggest that the presence of disability or frailty could contribute to development or progression of chronic diseases, possibly through the lower activity levels associated with the former two conditions, or through other pathways affecting some b”