Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care.

By L. Fried, Luigi Ferrucci, Jonathan D. Darer, J. Williamson, G. Anderson. The journals of gerontology. Series A, Biological sciences and medical sciences, 2004

3,896 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/a138fc3a54aadc4dfc804c3e38e7a34632b4b21b

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Citations in the corpus

Prevalence of Frailty in Community‐Dwelling Older Persons: A Systematic Review (2012, background): “This latter aspect has further stimulated the development of several instruments to measure frailty status, which in turn has indicated the dynamic nature of frailty over time.(18) The objectives of this literature review were to systematically compare the prevalence of frailty with regard to defini”
Frailty syndrome: an overview (2014, positive): “9% in the age-group 65–74 years to 25% in the age group older than 85 years.(14) The prevalence of frailty is higher in women than in men (8% versus 5%) and higher in African Americans than in Caucasians (13% versus 6% in the CHS and 16% versus 10% in the WHAS).”
Ageing and the epidemiology of multimorbidity (2014, background): “Ageing and multimorbidity contribute to frailty, which, in turn, confers a higher risk of a number of complications and poor outcomes such as falls, disability, hospitalisation and mortality [30, 31].”
Frailty Syndrome: A Transitional State in a Dynamic Process (2009, background): “The frailty state is characterized by slow, incomplete recovery after any new acute disease, injury or stress, confirming that the available functional reserves are insufficient to allow a complete recovery. These multisystem deregulations became clinically apparent either when unmasked by stressors”
A Comparison of Frailty Indexes for the Prediction of Falls, Disability, Fractures and Mortality in Older Men (2009, methodology): “In an attempt to standardize and operationalize the definition of frailty, geriatricians were systematically surveyed and a conclusion was reached that a critical mass of impairments added up to the phenotype of frailty.(2) Using data from the Cardiovascular Health Study (CHS), a phenotype was propo”
A global clinical measure of fitness and frailty in elderly people (2005, background): “The Clinical Frailty Scale mixes items such as comorbidity, cognitive impairment and disability that some other groups separate in focusing on physical frailty.(3) Although support exists for separate approaches,(28) consensus does not,(1,2) Rockwood et al”
Effects of physical exercise interventions in frail older adults: a systematic review of randomized controlled trials (2015, background): “Frailty is a multidimensional concept that influences several domains, such as gait, mobility, balance, muscle strength, motor processing, cognition, nutrition, endurance and physical activity [7], and it is directly related to adverse consequences, such as falls, disability, the need for longterm c”
Frailty: an emerging research and clinical paradigm--issues and controversies. (2006, background): “Conflicting ideas abound on the definition of frailty, what criteria should be used for its recognition, and its relationships with aging, disability, and chronic disease (5,7).”
Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society. (2012, background): “ty.(91,92) An operational definition for frailty by Fried and”
Outcome instruments to measure frailty: a systematic review. (2011, background): “A remarkable finding in frailty is that not all frail elderly experience the same symptoms and that frailty can be present in the absence of specific diseases, but more likely in combination with or as a consequence of co-morbidity (Fried et al., 2004; Fulop et al., 2010).”
Frailty Assessment in the Cardiovascular Care of Older Adults (2013, background): “A guiding principle is that frailty, disability, and comorbidity are inter-related but distinct entities (75).”
Transitions between frailty states among community-living older persons. (2006, background): “F RAILTY IS INCREASINGLY RECognized as a geriatric syndrome, distinct from disability and comorbidity, that results from a multisystem reduction in reserve capacity, confers high risk for an array of adverse outcomes, and is potentially amenable to prevention and remediation.(1) An important impedim”
The Tilburg Frailty Indicator: psychometric properties. (2010, background): “Frailty is not synonymous with either comorbidity or disability, because all 3 create specific care needs in older patients.(4) Frailty is considered a predisability state.”
Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group (2013, neutral): “…exhaustion and low physical activity (11). although the physical phenotype of frailty has been validated and used in a number of studies (14, 15, 19, 20) many investigators have suggested a broader multidomain phenotype of frailty which is not limited strictly to the physical domain yet…”