Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

By Matt Kaeberlein, R. Powers, Kristan K. Steffen, Eric A. Westman, Di Hu, N. Dang, Emily O. Kerr, Kathryn T. Kirkland, Stanley Fields, Brian K. Kennedy. Science, 2005

1,351 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/813eb6212935d6b984bb71c24c00b325bd2a9fe0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

In Geriatrics and Gerontology

In Molecular Biology

Citations in the corpus

mTOR Signaling in Growth, Metabolism, and Disease (2017, background): “, 2004), buddingyeast (Kaeberlein et al., 2005) as well as mice (Lamming et al.”
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal (2014, background): “Indeed, inhibition of ribosomal proteins or their regulators has been shown to extend lifespan in yeast and worms (Kaeberlein et al., 2005; Syntichaki et al., 2007).”
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, background): “170,175 There are several thoughts regarding the role of mTOR signaling in aging processes in mammalian systems.”
TOR signaling in growth and metabolism. (2006, background): “Also, partial inhibition of TOR function in yeast, worms, and flies results in a significant increase in the life span of these organisms, possibly by mimicking calorie restriction (reviewed in Martin and Hall, 2005, and Kaeberlein et al., 2005).”
mTOR signaling in growth control and disease (2012, positive): “Numerous reports indicate that inhibition of TOR activity induces life extension in yeast (Kaeberlein et al., 2005; Medvedik et al., 2007), worms (Vellai et al.”
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. (2007, background): “AMPK is known to regulate the TOR pathway in mammals [45], and mTOR/LET-363 and S6 kinase mutations have been found to extend lifespan in yeast, worms, and flies [44, 46–49].”
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease (2010, background): “Background: Reduced TOR signaling has been shown to significantly increase lifespan in a variety of organisms [1,2,3,4].”
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans (2008, background): “restriction cannot further extend the lifespans of yeast, worms or flies in which the TOR pathway has been inhibited [3,4,6].”