Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D.

By M. F. Holick, Rachael M. Biancuzzo, Tai C. Chen, E. Klein, A. Young, Douglass Bibuld, R. Reitz, Wael Salameh, Allen Ameri, A. Tannenbaum. Journal of Clinical Endocrinology and Metabolism, 2008

805 citations recorded by the source corpus.

Subfields: Cell Biology, Nutrition and Dietetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/c73e6c1778241fea3836c83332d5f1e1e2430afc

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Citations in the corpus

Position of the American Dietetic Association: vegetarian diets. (2009, background): “Although some research suggests that vitamin D-2 is less effective than vitamin D-3 in maintaining serum 25-hydroxyvitamin D levels (44) other studies find that vitamin D-2 and vitamin D-3 are equally effective (45).”
Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis (2012, methodology): “Two studies made specific reference to dropouts and sought to give some clarification about the reasons for dropout or noncompliance (15, 16), whereas 3 studies recorded dropout rates but gave no satisfactory detail as to the reasons for dropout (6, 7, 17).”
Nonclassic actions of vitamin D. (2009, background): “side chains, with the result that single doses of D2 lead to lower levels of circulating 25OHD than single doses of D3 (1, 2), although daily administration of D2 and D3 maintains comparable levels of 25OHD (3).”
Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. (2010, background): “However, comparisons of the relative potencies of vitamin D2 and D3 to increase serum 25-(OH)D levels in other populations have shown either lower or equal potency [125].”
Vitamin D for Health: A Global Perspective (2013, positive): “Although a recent metaanalysis indicated that vitaminD3 ismore efficacious at raising serum 25(OH)D concentrations than is vitamin D2, 2,102 several prospective studies have found them to be equally effective in raising and maintaining serum 25(OH)D levels in children and adults.(263,264) Holick et ”
IOF position statement: vitamin D recommendations for older adults (2010, background): “Some find that the two forms are equally effective in raising the serum 25OHD level [17] whereas others find that vitamin D3 gives a larger increment [18].”
Vitamin D deficiency: a worldwide problem with health consequences. (2008, background): “Our data (Figure 5), as well as our recent observation that vitamin D2 was as effective as vitamin D3 in raising the blood concentrations of 25(OH)D (91), however, calls into question whether this is really necessary.”
Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. (2011, background): “3.1 Evidence Some (47, 101, 128) but not all (129–131) studies have shown that both vitamin D2 and vitamin D3 are effective in maintaining serum 25(OH)D levels.”
The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, background): “1,25-(OH)2D is required for high-affinity binding and activation, but the RXR ligand, 9-cis retinoic acid, may either inhibit (37) or activate (38) 1,25-(OH)2D stimulation of gene transcription.”