Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene…

By H. Lo, S. Hsu, W. Xia, Xinyu Cao, Jin-Yuan Shih, Yongkun Wei, J. Abbruzzese, G. Hortobagyi, M. Hung. Cancer Research, 2007

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Subfields: Oncology

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Epithelial-mesenchymal transitions in development and disease. (2009, background): “EGF is known to induce EMT by promoting E-cadherin endocytosis (Lu et al., 2003), but it can also induce the expression of both Snail and Twist, repressing E-cadherin transcription among other targets (Lee et al., 2008; Lo et al., 2007).”
Epithelial–mesenchymal plasticity in carcinoma metastasis (2013, background): “Cytokines in the tumor microenvironment can also activate Stat3 via JAK kinases to induce Twist1 expression (Lo et al. 2007; Cheng et al. 2008).”
Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “have been associated with EMT induction, like the epidermal growth factor (EGF) via the Janus-activated kinase (JAK) pathway [114], the”
Dynamic EMT: a multi‐tool for tumor progression (2021, positive): “In particular, EGF is cooperating with other signaling pathways, e.g., IL 6 R/STAT 3 and TGF b , resulting in CDH 1 downregulation and enhanced cell motility and invasion (Lo et al , 2007 ; Tian et al , 2007 ; Uttamsingh et al , 2008 ; Colomiere et al , 2009 ).”
Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “In addition, EGF also induces the expression of SNAI1 and TWIST, leading to repression of the CDH1 promoter (153).”