Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

By Y. Hakak, John R. Walker, Cheng Li, Wing Hung Wong, K. Davis, Joseph D. Buxbaum, V. Haroutunian, A. Fienberg. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,231 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/809f115e631347613af5b67830a8cbcde0b996e4

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Citations in the corpus

A review of diffusion tensor imaging studies in schizophrenia. (2007, background): “There is also growing evidence to suggest that glial cells, particularly oligodendrocytes, which form myelin sheaths around axons, are abnormal in schizophrenia (Hakak et al., 2001; Uranova et al., 2001, 2004).”
Neuregulins: functions, forms, and signaling strategies. (2003, background): “[65] Y.”
Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. (2008, background): “Research suggests that the mGluR3 agonist NAAG might be increased in corticolimbic regions in schizophrenia as a result of downregulation of its catabolic enzyme, glutamate carboxypetidase II [41,143,144].”
The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications (2004, background): “Of note, microarray studies have implicated synaptic genes too (Hakak et al. 2001; Mirnics et al. 2001).”
The Human Brain Revisited: Opportunities and Challenges in Postmortem Studies of Psychiatric Disorders (2002, background): “For example, cDNA microarray studies of postmortem prefrontal cortex from subjects with schizophrenia have revealed abnormalities in the expression of multiple transcripts encoding proteins involved in specific domains of neural function (Mirnics et al. 2000, 2001a; Hakak et al. 2001; Vawter et al. ”
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015, background): “…findings across studies can be identified, including dysregulation of GABAergic signalling 102 ; downregulation of oligodendrocyte-and myelination-related genes 103 , mitochondrial function or energy metabolism 104 , and synaptic genes 105 ; and upregulation of immune and inflammatory genes 106 .”
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application (2001, methodology): “The average is taken over C(6, 2) = 15 pairwise comparison of two array sets for each probe set, and the correlation is calculated using probes that are not identified as an outlier in both array sets.”
DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity (2005, background): “Of particular note here, both microscopic (Uranova et al., 2001) and genetic studies (Hakak et al., 2001) demonstrate oligodendrocyte abnormalities in schizophrenia; these cells play a major role in protecting neuronal axons traveling within white matter fiber tracts by forming myelin sheaths.”