The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications

By Paul J. Harrison. Psychopharmacology, 2004

723 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/31c0e5f9bae8a0345398965dae9ce0f0beb1583b

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Psychiatry and Mental health

Citations in the corpus

Hippocampal plasticity in response to exercise in schizophrenia. (2010, background): “Pathological studies of the hippocampus in schizophrenia indicate lower neuronal size, possibly fewer neurons of specific types, and lower levels of a range of presynaptic proteins, particularly in the terminal fields of projections from the entorhinal cortex.(11,27) In adult rodents, newborn neuron”
Dysconnectivity in schizophrenia: where are we now? (2011, background): “To date much work has been done looking into the microcopic changes occurring at the cellular level in the white (and rey)matter of patients sufferingwith schizophrenia throughpostortem studies from which a number of cellular abnormalities ave been identified ranging from increases in microglia numb”
Glutamate and dopamine in schizophrenia: an update for the 21st century (2015, background): “Altered hippocampal activity is also seen in patients with schizophrenia (Harrison, 2004; Heckers et al., 1998; Malaspina et al., 2004) and prodromal psychosis, and has been linked to the subsequent development of schizophrenia (Schobel et al., 2013).”
Animal models of schizophrenia (2011, background): “For example, as in schizophrenic patients (Hirayasu et al., 2001; Harrison, 2004), a selective reduction in PFc volume occurs in isolation-reared rats (Day-Wilson et al., 2006; Schubert et al., 2009) accompanied by decreased dendritic spine density and morphology (Silva-Gomez et al., 2003; Pascual…”
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases (2015, background): “Patients with schizophrenia are found to have a lower hippocampus volume compared to healthy people, a finding that may be significant for the pathogenesis of the chronic psychotic symptoms (Harrison, 2004; Steen et al., 2006).”