Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium

By H. Praetorius, K. Spring. Journal of Membrane Biology, 2001

862 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/80852e27c49b5079427ad417104636a0c946b48d

How researchers see this paper

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In Genetics

1. B. Yoder
2. Courtney J. Haycraft

In Molecular Biology

1. Donald E. Ingber
2. A. Schier
3. B. Yoder
4. Courtney J. Haycraft
5. Carmel Majidi

In Pathology and Forensic Medicine

1. B. Yoder

Citations in the corpus

• The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. (2002, background): “How does the function of the primary apical cilium contribute to normal physiologic processes in renal epithelia and what role might the polycystins play in these processes? Recent data indicate that the primary apical cilium in renal epithelia functions as a mechanosensor (47), with flow-mediated d”
• Proteomic analysis of a eukaryotic cilium (2005, background): “We also found 27 EF hand-containing proteins that are potential Ca 2 binding proteins, consistent with the well-established role of Ca 2 in the control of flagellar behavior (Witman, 1993) and signaling (Bloodgood, 1992; Praetorius and Spring, 2001).”
• Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways (2005, background): “If tubular epithelial cells use noncanonical Wnt signaling to organize shape and function of the nephron, then how is the switch between Wnt pathways regulated? The onset of glomerular filtration and production of primary urine marks a new stage in the development of a nephron, exposing tubular epit”
• Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells (2003, background): “Recent work has shown that the primary cilium of the kidney epithelium mediates sensation of mechanical signals produced by apical fluid shear stress and its transduction into an intracellular Ca 2+ signaling respons”
• The Primary Cilium as a Complex Signaling Center (2009, background): “Subsequent data showed that primary cilia on renal epithelium function as mechanosensors and that deflection of these cilia in response to fluid movement initiated an intracellular calcium signal [17,18].”
• Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis (2005, background): “Cell culture studies of PKD1 and PKD2, the genes responsible for autosomal dominant polycystic kidney disease, suggests that they act together in epithelial cells to mediate calcium entry upon flow-induced cilium deflection (Nauli et al., 2003; Praetorius and Spring, 2001).”