The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia.

By B. Yoder, X. Hou, L. Guay-Woodford. Journal of the American Society of Nephrology, 2002

930 citations recorded by the source corpus.

Subfields: Genetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/efa911319b16f40dad92b585cc755a8cb4717dca

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In Genetics

1. P. Beales
2. Haitao Li
3. B. Yoder
4. Courtney J. Haycraft
5. N. Katsanis

In Pathology and Forensic Medicine

1. B. Yoder

Citations in the corpus

• Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. (2004, methodology): “Real-time RT-PCR was performed in 40 cycles of ton, 1997) cells were performed as described with a 1:500 dilution 95 C for 15 s and 60 C for 1 min using the ABI PRISM 7000 Sequence (Yoder et al., 2002).”
• Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut (2005, background): “Furthermore, pkd2, which encodes a component of a cation channel (Hanaoka et al., 2000) that localizes to cilia in mouse cells (Yoder et al., 2002), has been shown to function during zebrafish kidney development (Sun et al., 2004) and LR determination (data not shown).”
• Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis (2005, background): “…to become cystic (Barr et al., 2001; Blacque et al., 2004; Fan et al., 2004; Kim et al., 2004; Morgan et al., 2002; Murcia et al., 2000; Mykytyn et al., 2004; Otto et al., 2003; Pazour et al., 2000; Pazour et al., 2002; Qin et al., 2001; Sun et al., 2004; Taulman et al., 2001; Yoder et al., 2002).”
• Ciliopathies: an expanding disease spectrum (2011, background): “Ciliary dysfunction has been shown to underlie the pathogenesis of both these cystic disorders following the identification and localisation of fibrocystin and nephrocystins, the genes mutated in ARPKD and in NPHP respectively, to the primary cilium of cholangiocytes and renal tubular epithelial cel”
• The ciliopathies: an emerging class of human genetic disorders. (2006, background): “In the congenital polycystic kidney (cpk) mutant mouse, cystin, the protein product of cpk, is present in the cilia of renal epithelial cells (142).”