Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice

By F. Ishikawa, M. Yasukawa, B. Lyons, S. Yoshida, T. Miyamoto, G. Yoshimoto, Takeshi Watanabe, K. Akashi, L. Shultz, M. Harada. 2005

863 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/8054a57a5d310db21925182d7482c551648864f6

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In Hematology

1. Irving L. Weissman
2. R. Majeti
3. Christopher Y. Park

In Immunology

1. Irving L. Weissman
2. R. Majeti

Citations in the corpus

• Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region (2007, methodology): “To understand the functional properties of human LS cells, we developed a primary human AML xenotransplantation model using newborn nonobese diabetic/severe combined immunodeficient/interleukin (NOD/SCID/IL)2rγ null mice carrying a complete null mutation of the cytokine γc upon the SCID backgroun”
• Humanized mice in translational biomedical research (2007, background): “The third breakthrough was the humanization of immunodeficient mice homozygous for targeted mutations at the interleukin-2 receptor (IL-2R) γ-chain locus ( Il2rg ; also known as the common cytokine-receptor γ-chain, γc”
• Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. (2007, methodology): “Transplantation of 20,000 Lin CD34+CD38 human cord blood cells into tem Cell 1, 635–645, December 2007 ª2007 Elsevier Inc. 635 sublethally irradiated newborn pups resulted in multilineage engraftment, with significant numbers of human cells present in the peripheral blood (Ishikawa et al., 2005).”
• Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo (2010, neutral): “To evaluate this approach, we optimized the delivery of CCR5 -specific ZFNs to human CD34 + HSPCs and transplanted the modified cells into nonobese diabetic/severe combined immunodeficient/interleukin 2rγ null (NOD/SCID/IL2rγ null ; NSG) mice, which support both human hematopoiesi”
• Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates (2009, methodology): “NOD-SCIDγ c null mice were kept and bred in a specific pathogen-free facility at the University of Leuven and were pre-conditioned with 100 cGy (Linear accelerator, University Hospital Gasthuisberg, Belgium) one day before injection of CD34 + cells, as described previousl”