Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

By L. Mátés, M. Chuah, Eyayu Belay, B. Jerchow, N. Manoj, A. Acosta-Sanchez, D. Grzela, Andrea Schmitt, Katja Becker, J. Matrai and 9 more. Nature Genetics, 2009

949 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4d8937b7867ee8cdcee2c0d43fd74c6c9795956b

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In Molecular Biology

1. A. Bradley
2. K. Yusa

Citations in the corpus

• Zinc finger nuclease-mediated CCR5 knockout hematopoietic stem cell transplantation controls HIV-1 in vivo (2010, neutral): “, although, more recently, less toxic outcomes have been describe”
• A hyperactive piggyBac transposase for mammalian applications (2011, background): “The most recent version of the Sleeping Beauty transposase (SB100) shows a marked hyperactivity compared with the original transposase (22).”