Humanized mice in translational biomedical research

By L. Shultz, F. Ishikawa, D. Greiner. Nature reviews. Immunology, 2007

1,414 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/8effdcd48425c2045e6a6519e66aab9f3caec6ac

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In Cell Biology

1. J. Massagué
2. K. Strebhardt
3. A. Ullrich

In Immunology

1. J. Massagué
2. X. Zhang
3. E. Batlle

Citations in the corpus

• Dependency of colorectal cancer on a TGF-beta-driven programme in stromal cells for metastasis initiation (2012, background): “immunocompromised mice of the NOD/SCID interleukin-2 receptor gamma chain null strain (NSG) (Shultz et al., 2007).”
• Maximizing mouse cancer models (2007, background): “To date, humanizing the murine immune system has consisted of ablating the endogenous immune system followed by engraftment with human immune cell”