Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.

By D. Kelley, Jing He, Elizabeth V. Menshikova, V. Ritov. Diabetes, 2002

2,388 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/802269ab7e59440e6a88a85a005f085901e89c29

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Citations in the corpus

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “In contrast, lipid droplets are distributed more diffusely throughout the cell in type 2 diabetics and are not in close proximity to the mitochondria, which generally are smaller and display reduced oxidative enzyme activity (76).”
Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities (2011, neutral): “Although there are some studies to the contrary, decreased mitochondrial function and/or content are associated with insulin resistance in animal models as well as in human subjects (44, 171, 194, 365).”
SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome (2011, positive): “A number of abnormalities in mitochondria have been identified in prior studies as key pathogenic mechanisms in the development of the metabolic syndrome, including reduced mass (Kelley et al., 2002), altered morphology (Civitarese et al.”
Mitochondrial dysfunction and oxidative stress in metabolic disorders - A Step towards mitochondria based therapeutic strategies (2016, background): “A recent study done on diabetic and obese patients established the impaired glucose and lipid homeostasis in skeletal muscle [116].”
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “…Exacerbates the Effects of Nutrient Excess on Bioenergetic Efficiency Some of the first observations that associated fragmentation with excess nutrients were the decreased size of mitochondria in muscle from type-2-diabetic and obese humans or mouse models (Bach et al., 2003; Kelley et al., 2002).”