Accelerated age-related CpG island methylation in ulcerative colitis.

By J. P. Issa, N. Ahuja, M. Toyota, M. Bronner, T. Brentnall. Cancer Research, 2001

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Classification of colorectal cancer based on correlation of clinical, morphological and molecular features (2007, background): “Chronic inflammation in the context of ulcerative colitis has also been linked with DNA methylation.(102)”
Aberrant epigenetic landscape in cancer: how cellular identity goes awry. (2010, background): “In addition, chronic inflammation has been proposed as possible inducer of aberrant methylation in liver cancers or ulcerative colitis-associated colon cancers (Kondo et al., 2000; Issa et al., 2001).”
Cancer epigenetics. (2005, background): “Some of these changes have been suggested to be age-related (121,127), whereas others have been proposed to be premalignant (123,128), in some cases associated with environmental risk exposures (129) and/or diet (130).”
Inflammation and cancer: An ancient link with novel potentials (2007, background): “Methylated CpG sites are also prone to the deamination, leading to missense mutations in cancer-related genes.105 Evidence supports an association between chronic inflammation and hypermethylation both in the presence and absence of microbial infection.101 H. pylori-infected patients with and withou”
Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. (2004, background): “Given the importance of the CIN pathway in CAC, it will be important to more directly study the role of inflammation in this process.”