Classification of colorectal cancer based on correlation of clinical, morphological and molecular features

By J. Jass. Histopathology, 2007

1,438 citations recorded by the source corpus.

Subfields: Cancer Research, Pathology and Forensic Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/9866c0d20cc3481050f45f35826edb9100ae66e9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Angeliki Voulgari
2. Edward L. Giovannucci
3. Charlotte Soneson
4. Mauro Delorenzi
5. D. Snover
6. A. Pintzas

In Pathology and Forensic Medicine

1. Angeliki Voulgari
2. Edward L. Giovannucci
3. D. Snover
4. A. Pintzas

In Surgery

1. Angeliki Voulgari
2. Edward L. Giovannucci
3. D. Snover
4. A. Pintzas

Citations in the corpus

• Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications (2009, background): “When a CRC is found with tumor infiltrating lymphocytes, a Crohn’s-like lymphocytic response, an excess of mucin, or signetring cell pathology with poor differentiation, the informed pathologist should consider testing for MSI (50, 51).”
• Colorectal carcinoma: Pathologic aspects. (2012, background): “Colorectal cancers with CpG island methylator phenotype (CIMP) are characterized by epigenetic loss of function of tumor suppressor genes without mutations (49,113).”
• Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value (2013, background): “GEP studies on CRC have been only poorly reproducible, possibly because CRC is composed of distinct molecular entities that may develop through multiple pathways on the basis of different molecular features [9–11].”
• Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN and FOCUS studies (2014, background): “Colorectal cancer (CRC) is a heterogeneous disease arising through different pathways.(1, 2) Three molecular pathways are well known to be involved in the multistep process of colorectal carcinogenesis, including the chromosomal instability (CIN) pathway, the mutator pathway (microsatellite instabil”
• Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “Notably, the frequency of budding in colorectal cancer has been reported to correlate with microsatellite stability and high frequency of APC mutations [175], suggesting the need for particular genetic alterations and building the first rules to its identification.”
• CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer (2008, result): “[38, 39] Compared to patients whose tumors were both MSS and CIMPlow/0, those with CIMP-high tumors experienced a significant reduction in colon cancer-specific mortality, regardless of MSI status.”
• Update on the serrated pathway to colorectal carcinoma. (2011, background): “) regarding colorectal pathways was recently summarized in review by the late Jeremy Jass, and this article is recommended reading for anyone wishing to understand the multiple pathways to colorectal carcinoma [2].”
• Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. (2014, background): “The CpG island methylator phenotype (CIMP) pathway goes along with the occurrence of serrated precursor lesions and is also strongly related to the MSI pathway, notably through frequent methylation of the MLH1 promoter, which confers MSI high status [1] .”