Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells.

By H. Imai, Y. Nakagawa. Free Radical Biology & Medicine, 2003

752 citations recorded by the source corpus.

Subfields: Biochemistry, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7f6da16691e7d6f14ad88c0d36329155302d5742

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. M. Lambros
2. A. Massie
3. H. Forman
4. Sylvia B. Smith
5. V. Ganapathy
6. Ying Huang
7. Hiroyuki Tsutsui
8. Peter W. Kalivas

In Immunology

1. T. Vanden Berghe
2. H. Forman
3. Hiroyuki Tsutsui
4. Peter Vandenabeele
5. Guido Kroemer

In Molecular Biology

1. Peter Vandenabeele
2. T. Vanden Berghe
3. H. Forman
4. Yau-Huei Wei
5. Hsin-Chen Lee
6. Hiroyuki Tsutsui
7. Peter W. Kalivas
8. P. Maher

Citations in the corpus

• Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. (2005, background): “Moreover, increased ROS may induce the peroxidation of cardiolipin in the mitochondrial inner membrane, which triggers dissociation of cytochromec from cardiolipin (Imai & Nakagawa, 2003).”
• Role of pyroptosis in inflammation and cancer (2022, background): “Additionally, glutathione peroxidase 4 (GPX4) can suppress lipid peroxidation to inhibit phospholipase C gamma 1 (PLCG1), thereby preventing the production of GSDMD-NT, which can be improved by the antioxidant activity of vitamin E to promote the survival rate in sepsis [113, 114].”
• Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. (2006, background): “These enzymes include glutathione peroxidase (GPx), phospholipid hydroperoxide glutathione peroxidase (PHGPx: cytosolic, mitochondrial and nuclear isoforms), Mnsuperoxide dismutase (MnSOD: mitochondrial matrix), Cu/Zncontaining dismutase (Cu/ZnSOD: cytoplasm and mitochondrial intermembrane space), a”
• The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, positive): “GPx4 is unique in its ability to reduce lipid hydroperoxides embedded in membranes (97).”
• Technical (1960, neutral): “1C), indicating that these transcripts correspond to KIR3DS1 expression.”
• Glutathione: Overview of its protective roles, measurement, and biosynthesis (2008, background): “Phospholipid hydroperoxide glutathione peroxidase (PHGPx or GPx IV) can reduce lipid peroxides to lipid alcohols (Imai and Nakagawa, 2003).”
• Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity (2020, positive): “in rat basophile leukemia cells (RBL2H3 cells) (36), suggesting that nonmitochondrial GPx4 plays a limited role in mitochondria (37).”
• From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health (2007, neutral): “Unlike other GPxs, GPx4/PHGPx can reduce phospholipid-and cholesterol-hydroperoxides directly, by using electrons from protein thiols as well as from glutathione in mammalian cells (156).”