Bacterial resistance to antibiotics: enzymatic degradation and modification.
By Gerard D. Wright. Advanced Drug Delivery Reviews, 2005
887 citations recorded by the source corpus.
Subfields: Infectious Diseases, Molecular Biology, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/7f3b1a795f318a34441e31ae4f791f6a23fa26d2
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In Infectious Diseases
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Citations in the corpus
- The antibiotic resistome: the nexus of chemical and genetic diversity (2007, background): “For example, enzymes that inactivate antibiotics such as β-lactamases and aminoglycoside kinases are class (and sometimes compound) specifi”
- Acquired Antibiotic Resistance Genes: An Overview (2011, background): “Ambler classes A, C, and D include the β-lactamases with serine at their active site, whereas Ambler class B β-lactamases are all metallo-enzymes who require zinc as a metal cofactor for their catalytic activities (Ambler, 1980; Bradford, 2001; Paterson and Bonomo, 2005; Wright, 2005; Poirel et al.,”
- Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems (2008, background): “Several sophisticated mechanisms are involved in these resistance phenotypes, including (i) enzymatic inactivation of antibiotics (101, 531), as seen for -lactams (43); (ii) modification of the antibiotic target (for example, enterococci synthesize a cell wall precursor with a modified terminal dipe”
- Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli. (2007, background): “The ability of pathogenic bacteria to resist antimicrobial agents has emerged in recent years and is a major health problem [6,7].”
- Antibiotic Resistance Is Prevalent in an Isolated Cave Microbiome (2012, background): “Within the isolates, we detected no inactivation of aminoglycosides, the lincosamide clindamycin, or chloramphenicol; antibiotics where enzymatic inactivation is a prevalent resistance mechanism in surface bacteria (Table 1) [33].”
- Synergism between natural products and antibiotics against infectious diseases. (2008, background): “The various enzymatic strategies that lead to antibiotic inactivation are through hydrolysis, group transfer or redox mechanisms (Wright, 2005).”