The antibiotic resistome: the nexus of chemical and genetic diversity

By Gerard D. Wright. Nature Reviews Microbiology, 2007

1,340 citations recorded by the source corpus.

Subfields: Molecular Medicine, Pharmacology, Pollution

View Paper: https://www.semanticscholar.org/paper/c947bcc7de1cffae7a835e57a7edeb4df84416cf

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Citations in the corpus

Natural product discovery: past, present, and future (2016, background): “Sequence information also revealed the high frequencies of biosynthetic clusters of the NPs discovered in the early discovery period, as well as the presence of antibiotic “resistomes” (multiple genes for antibiotic resistance) among soil isolates [131].”
Detection and fate of antibiotic resistant bacteria in wastewater treatment plants: a review. (2013, background): “Thus, concerns have been raised about the potential impact of antibiotic remnants in the aquatic environment (Sarmah et al., 2006; Wright, 2007; Kemper, 2008).”
Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens. (2011, background): “There is also considerable interest in characterizing the antibiotic resistome more generally from environmental samples (D’Costa et al., 2006; Wright, 2007), with a view to predicting novel resistance mechanisms and informing the rational development of new antibiotics.”
Strategies and molecular tools to fight antimicrobial resistance: resistome, transcriptome, and antimicrobial peptides (2013, background): “To select genetic markers related to the bacterial resistome in this holistic point of view remains as an important challenge (Islam et al., 2001; Taggart et al., 2003; Wright, 2007).”
The biology and future prospects of antivirulence therapies (2008, background): “In our current battle against infectious diseases, clinicians are limited to the use of antibiotics that stimulate bacterial evolutio”
Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens (2018, background): “Therefore, it is proposed that to get a full understanding of the origin of resistance, one must consider the pan-microbial genome consisting of antibiotic producers, pathogens, cryptic genes, and precursor genes (Wright, 2007; Nesme and Simonet, 2015).”
Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance (2017, background): “KLEBSIELLA PNEUMONIAE RESISTOME The resistome is defined as the collection of all the genes that confer antibiotic resistance (Wright 2007).”
Antibiotic resistance in the environment: a link to the clinic? (2010, background): “The concept of the antibiotic resistome has been advanced to serve as a framework for understanding the ecology of resistance on a global scale [14].”
Antibiotics induce redox-related physiological alterations as part of their lethality (2014, neutral): “peroxide? Arch Biochem Biophys 525(2):145–160.”