The anaphase promoting complex/cyclosome: a machine designed to destroy

By J. Peters. Nature reviews. Molecular cell biology, 2006

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Cell cycle, CDKs and cancer: a changing paradigm (2009, background): “The molecular pathways that regulate SAC function have been extensively reviewe”
Understanding eukaryotic linear motifs and their role in cell signaling and regulation. (2008, background): “Both motifs allow the timely recruitment of the anaphasepromoting ubiquitin ligase complex APC/C, which in turn initiates ubiquitination and subsequent proteasomemediated degradation of the protein (62, 63).”
RING domain E3 ubiquitin ligases. (2009, background): “More detailed accounts of APC/C regulation by phosphorylation can be found elsewhere (132, 133).”
Protein Metamorphosis: The Two-State Behavior of Mad2 (2008, background): “At the metaphase-to-anaphase transition, a ubiquitin ligase complex called the anaphase-promoting complex or cyclosome (APC/C) ubiquitinates securin and cyclin B (Peters, 2006; Yu, 2007).”
The spindle-assembly checkpoint in space and time (2007, background): “Separase is required to cleave the cohesin complex that holds sister chromatids together, and cohesin cleavage is required to execute anaphas”
Shared and separate functions of polo-like kinases and aurora kinases in cancer (2010, background): “Once proper chromosome alignment is established, cyclin B and securin are degraded by the anaphase-promoting complex/cyclosome bound to CDC20 (APC/C CDC20”