Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

By M. Dumas, R. H. Barton, A. Toye, Olivier Cloarec, C. Blancher, Alice R. Rothwell, Jane F. Fearnside, R. Tatoud, V. Blanc, John C. Lindon and 6 more. Proceedings of the National Academy of Sciences of the United States of America, 2006

1,034 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/7e53f36cdf8c818dc0f38ed99cef2c9b28585291

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Citations in the corpus

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis (2010, background): “insulin resistance, which suggests that the microbiota and/or microbiota-regulated host factors might influence energy absorption, adiposity, systemic inflammation, and development of insulin resistance.(35,36) Endotoxin and Its Role in Obesity.”
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. (2008, background): “Each transporter involves three linked enzymes that act as phosphoryl group recipients and donors: two are cytoplasmic enzymes that act on all imported PTS carbohydrates (HPr and EI), and the other is a carbohydrate-specific complex (EII) comprising one or two hydrophobic integral membrane domains (”
Symbiotic gut microbes modulate human metabolic phenotypes (2008, background): “prausnitzii is particularly intriguing because dimethylamine is a product of microbial catabolism of dietary choline (by trimethylamine) that has previously been linked to high-fat diet-induced insulin resistance, fatty liver, and type 2 diabetes in experimental mice (10), and in other studies a low”
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease (2009, neutral): “9) 0 Villi ZO-1 nuclei (%) 7 (4-12) 1 (0-3) 0.”
Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows (2010, background): “These studies allow one to explore the symbiotic complexity between the host and its microbiota as affected by diet, and to unravel the effects of diet on the development of metabolic diseases (Dumas et al. 2006).”
Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance (2013, background): “Accumulating evidence indicates that the gut microbiota is involved in host metabolism by increased energy extraction, immune system modulation, and altered lipid metabolism, all which have been demonstrated to contribute to progression to T2DM [13,50–52].”
New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? (2010, background): “Results are convincing in that new metabolic effects have been unravelled using this new open approach, for example, the role of symbiotic microbiota in triggering diet-induced mechanisms of steatosis((337)) or some specific metabolic pathway disturbances in diabetic rats((338)), thus improving our ”