Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

By L. Miele, V. Valenza, G. La Torre, M. Montalto, G. Cammarota, R. Ricci, R. Mascianà, A. Forgione, M. Gabrieli, G. Perotti and 5 more. Hepatology, 2009

1,398 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/a0f3dc462532d5289d5ed01071ddb3626c49e952

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Herbert Tilg
2. M. Pinzani
3. A. Moschen
4. Patrice D Cani
5. E. Tsochatzis
6. E. Buzzetti
7. Gideon M. Hirschfield

In Molecular Biology

1. Patrice D Cani
2. Herbert Tilg
3. H. Smidt
4. James Kinross
5. Julian R. Marchesi
6. M. Schoeler
7. Severine Vermeire
8. Robert Caesar

In Neurology

1. Patrice D Cani
2. Severine Vermeire
3. M. Vancamelbeke

Citations in the corpus

• Human Intestinal Barrier Function in Health and Disease (2016, background): “Changes in TJ protein expression and distribution are suggested as critical factors in the impairment of gut barrier function and subsequent alterations in gut permeability observed in nonalcoholic fatty liver disease patients.(109)”
• Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages (2018, neutral): “One well-known trigger is exposure to LPS. Increased bacterial translocation from the digestive tract has been observed in NASH patients (Miele et al., 2009).”
• The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). (2016, background): “[138] Miele L, Valenza V, La Torre G, et al.”
• Gut Microbiota and Immune System Interactions (2020, background): “Gut barrier dysfunctions observed in patients with mild to moderately active CD result mostly from the up-regulation of claudin 2, and the down-regulation and redistribution of claudins 5 and 8, leading to discontinuous tight junctions [114,115].”
• Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes (2017, background): “This may avoid inflammatory activation of endothelial and Kupffer cells in the liver with concomitant hepatocyte dysfunction, as usually observed in response to a western-type high-fat diet or during non-alcoholic fatty liver disease [165, 166].”
• The gut microbiota and host health: a new clinical frontier (2015, background): “39”
• The intestinal barrier: a fundamental role in health and disease (2017, background): “Ethanol as well as its main metabolite, acetaldehyde, has been found to decrease small and large intestinal barrier function by direct damage to the epithelial cells; disruption of the TJs, AJs, and cytoskeleton; and activation of oxidative stress responses.”
• Intestinal microbiota in patients with nonalcoholic fatty liver disease (2013, neutral): “ALP (U/L) 65 (49-98) 64 (42-105) 77 (37-114)”