Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

By Herbert Tilg, A. Moschen. Hepatology, 2010

2,421 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives (2020, background): “HSCs activation by oxidative stress and inflammation plays a leading role in NASH disease progression and fibrosis development [213].”
NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications (2020, neutral): “44 Various lipid-related pathways may ‘drive’ hepatic inflammatory pathways in NAFLD.”
Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease (2018, background): “This first hypothesis has been subsequently revised in a “multiple parallel-hit”model in which, in the presence of a significant accumulation of fat in hepatocytes and systemic and hepatic insulin resistance, multiple simultaneous alterations lead to an imbalance between the antilipotoxic protection”
MASLD: a systemic metabolic disorder with cardiovascular and malignant complications (2024, background): “39 These ‘multiple hits’ can activate proinflammatory cascades, including various inflammatory cytokines and inflammasomes, such as the NLR family pyrin domain containing 3 (NLRP3).”
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). (2016, background): “Furthermore, enteric bacteria suppress the synthesis of fasting-induced adipocyte factor (Fiaf) resulting in increased lipoprotein lipase activity and increased triglyceride accumulation [51].”