Vitamin D and Diabetes Let the Sunshine In
By S. Penckofer, J. Kouba, D. Wallis, M. Emanuele. The diabetes educator, 2008
852 citations recorded by the source corpus.
Diabetes is a leading cause of cardiovascular disease. Persons with diabetes are at greater risk for early cardiac mortality, and for repeat events if they survive their first cardiac event. Recently, low serum concentrations of vitamin D have been associated with increased risk for cardiac events. Evidence indicates that persons with diabetes have lower serum concentrations of vitamin D. In addition, persons at risk for diabetes or metabolic syndrome have inadequate serum concentrations of vitamin D. This review will assess the evidence relative to the impact of vitamin D in the development of diabetes, metabolic syndrome, and diabetes complications. Studies that address vitamin D and its impact on metabolic outcomes as well as possible mechanisms of action are provided. Finally, the assessment and suggested treatment for vitamin D deficiency is addressed. Effective detection and treatment of inadequate vitamin D concentrations in persons with diabetes or those at risk for diabetes may be an easy and cost-effective therapy which could improve their long-term health outcomes as well as their quality of life.
Subfields: Nutrition and Dietetics, Pathology and Forensic Medicine, Physiology
View Paper: https://www.semanticscholar.org/paper/7de443431c2c2082eb064d2f20219b1301dcddf6
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In Nutrition and Dietetics
In Pathology and Forensic Medicine
Citations in the corpus
- Vitamin D and Immune Function (2013, background): “On the other hand, there is evidence that vitamin D supplementation early in life is a protective factor against the development of T1D (reviewed in [104,105]).”
- Vitamin effects on the immune system: vitamins A and D take centre stage (2008, background): “VD 3 deficiency might also predispose to type I diabete”
- Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention (2014, background): “In addition, vitamin D supplementation is recognized as a promising and inexpensive therapy, which may decrease the risk of T2DM and improve glycemic parameters in T2DM patients [67].”
- Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “For type 1 diabetes, multiple studies have evaluated the impact of vitamin D intake during pregnancy and/or early life and the prevalence of diabetes or diabetes-related autoimmunity (474, 475).”
- Type 1 diabetes: etiology, immunology, and therapeutic strategies. (2011, background): “The search for genetic polymorphisms in the vitamin D receptor (VDR) has yielded conflicting results on the correlation with T1D in the majority of studies (276), and a recent meta-analysis concluded that there was no such evidence (170).”
- Vitamin D physiology. (2006, background): “by downregulation of dendritic and Th1 cells, suppression of the antigen-presenting capacity of macrophages and dendritic cells and promotion of Th2 lymphocytes (Mathieu et al., 2005).”