Convergence of Wnt, ß-Catenin, and Cadherin Pathways

By W. Nelson, R. Nusse. Science, 2004

2,358 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7dc1558853fd6d7504e14ccbbdb86109c1d30b56

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. A. von Haeseler
4. Heiko A. Schmidt
5. C. Logan
6. K. Willert
7. C. Niessen
8. B. Toole

Citations in the corpus

• Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression (2007, background): “This is often a preliminary step triggering EMT as this releases b-catenin to participate in Wnt pathway signaling (Nelson and Nusse, 2004).”
• Derailed endocytosis: an emerging feature of cancer (2008, background): “The best-studied components of AJs are E-cadherin and β-catenin ; E-cadherin traps β-catenin at the cytoplasm, but loss of this interaction enables nuclear translocation of β-catenin and activation of the Wnt pathway, which controls polarity and influences cell migratio”
• Cadherins and cancer: how does cadherin dysfunction promote tumor progression? (2008, background): “A more subtle alternative is that the high-affinity cadherin–b-catenin interaction may be disrupted during oncogenesis, thereby perturbing E-cadherin adhesion as well as releasing b-catenin to signal (Nelson and Nusse, 2004).”
• The Wnt signaling pathway in development and disease. (2004, methodology): “For a discussion of current data that examines connections between cell adhesion and Wnt signaling, we direct the reader to Nelson & Nusse (2004).”
• The role of the Rho GTPases in neuronal development. (2005, background): “-Catenin is a component of the cadherin/catenin complex that helps to stabilize the actin cytoskeleton and mediate cell adhesion (Nelson and Nusse 2004).”
• Hyaluronan: from extracellular glue to pericellular cue (2004, background): “In addition, cooperativity between the WNT signalling pathway and the dispersal of adherens junctions leads to the accumulation of β-catenin in a complex with the transcription factor TCF4/LEF and to the activation of genes that are involved in EM”