Engineering Yeast Transcription Machinery for Improved Ethanol Tolerance and Production

By H. Alper, J. Moxley, Elke Nevoigt, Gerald Fink, G. Stephanopoulos. Science, 2006

803 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7dadab11982e362a5e8f21f7e2746f26fb374831

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In Molecular Biology

Citations in the corpus

Adaptive laboratory evolution – principles and applications for biotechnology (2013, background): “Microbial cells are of special importance for biotechnological applications and bacteria and yeasts are used for many biotechnological tasks, ranging from biofuel production [1-3], commodity chemical synthesis [4,5], through to the production of industrial and biopharmaceutical proteins [6-8].”
Fermentative butanol production by clostridia (2008, background): “As illustrated by Alper et al. (2006) for ethanol tolerance in yeast, this may be realized by altering global transcription regulators.”
Synthesis of DNA fragments in yeast by one-step assembly of overlapping oligonucleotides (2009, background): “The capacity of the yeast Saccharomyces cerevisiae to take up and recombine DNA fragments has made it a model eukaryote for studying numerous cellular processes and human diseases (6–8), and a platform for biofuel production (9) and drug discovery (10,11).”
Enrich: software for analysis of protein function by enrichment and depletion of variants (2011, background): “These measurements are essential in such applications as protein engineering, drug development, protein design and genome sequence analysis.”
Ethanol fermentation technologies from sugar and starch feedstocks. (2008, background): “Indeed, the mechanisms of ethanol inhibition are still not clear in many aspects, especially at the genetic level, and the investigations in this field are ongoing (Alper et al., 2006).”
Yeasts in sustainable bioethanol production: A review (2017, background): “analysis has revealed the structure and DNA binding elements of these regulatory proteins [27].”
Technological trends, global market, and challenges of bio-ethanol production. (2010, positive): “More recently, novel approaches have been devised and applied to improve ethanol production by S. cerevisiae, particularly genome shuffling (Shi et al., 2009; Hou, 2009) and global transcription machinery engineering (gTME) (Alper et al., 2006).”
Progress in Metabolic Engineering of Saccharomyces cerevisiae (2008, background): “Indeed, gTME has been demonstrated to successfully improve yeast tolerance to high sugar and ethanol concentrations (9).”
Metabolic engineering of Escherichia coli for 1-butanol production. (2008, neutral): “, 1998 ; Alper et al .”