Intestinal inflammation and cancer.

By T. Ullman, S. Itzkowitz. Gastroenterology, 2011

1,112 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Hepatology

View Paper: https://www.semanticscholar.org/paper/7da1ad591440ec1e0e06a8ddce7bfc5b1c69779c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. L. Peyrin-Biroulet
2. T. Jess
3. Christine Rungoe
4. Grace Y. Chen
5. F. Greten
6. S. Grivennikov

In Genetics

1. L. Peyrin-Biroulet
2. T. Jess
3. Christine Rungoe
4. Patrick D. Schloss
5. F. Greten

In Hepatology

1. L. Peyrin-Biroulet
2. T. Jess
3. Christine Rungoe
4. F. Greten

Citations in the corpus

• Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies. (2012, methodology): “Subsequently, pooled SIRs with 95% CIs across cohorts were calculated for (1) CRC overall, (2) CRC in women and men separately, (3) CRC according to age at IBD diagnosis, and (4) CRC in patients with extensive colitis.”
• Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “XO mainly functions in the intestinal mucosa, generating ROS and leading to GI tract injuries [19], while MPO is active in inflamed mucosa in UC patients and contributes to the progression of malignancies [20].”
• Chronic Inflammation and Cytokines in the Tumor Microenvironment (2014, background): “Therefore, differential phosphorylation of SMAD2 and SMAD3 by TGF𝛽 receptor activation promotes their translocation into the nucleus, where they form a complex with SMAD4, further bind to DNA, associate with other transcription factors, and induce gene expression [82].”
• The Gut Microbiome Modulates Colon Tumorigenesis (2013, background): “Chronic inflammation of the colon leads to the production of various inflammatory cytokines and reactive oxygen species that work in concert to generate a tumor microenvironment that promotes carcinogenesis (21, 23, 24).”
• Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “Increased MPO activity is also found in inflamed mucosa in ulcerative colitis, and this may contribute to the progression to malignancy associated with this disease (293).”
• Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “For example, while IBD predisposes to colitis associated cancer (CAC), only around 2% of CRC are preceded by intestinal inflammation (Ullman and Itzkowitz, 2011).”