Tissue-specific expression and regulation of sexually dimorphic genes in mice.

By Xia Yang, Eric E. Schadt, Susanna S. Wang, Hui Wang, A. Arnold, L. Ingram-drake, T. Drake, Aldons J. Lusis. Genome Research, 2006

874 citations recorded by the source corpus.

Subfields: Genetics, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/7d36f52a32be709cad5677977943854d8b44c442

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In Genetics

Citations in the corpus

The evolution of sex-biased genes and sex-biased gene expression (2007, background): “Recent work indicates that the second factor is a major contributor to intersexual differences in gene expressio”
Nothing in Genetics Makes Sense Except in Light of Genomic Conflict (2013, background): “For example, in mice at least 10,000 genes (most of which are autosomal) have sex-specific differences in gene expression within somatic tissues (Yang et al. 2006).”
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus (2016, background): “brain and 70% in liver, with mostly small effects (185).”
The sirtuin SIRT6 regulates lifespan in male mice (2012, background): “In agreement with the sexual dimorphism in liver gene expressio”
Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes (2009, background): “The sexual dimorphism of liver gene expression is not confined to DMEs; it is quite extensive and affects more than 1000 individual genes in both rats and mice (Clodfelter et al., 2006, 2007; Yang et al., 2006; Wauthier and Waxman, 2008).”
Sexual selection in females (2009, background): “brains, experience the effects of sex-differential gene expression (Yang et al. 2006).”
Mapping the Genetic Architecture of Gene Expression in Human Liver (2008, background): “TheBXH cross on an ApoE null background (BXH/apoE) was previously described [41].”
Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility (2010, background): “as environmental exposures [11,12], metabolic conditions [13], ageing [14,15] or gender [16–17].”
Sex Bias in Neuroscience and Biomedical Research (2010, neutral): “…of more than 23,000 mouse transcripts of active genes, ranging from 14% in the CNS to 70% in the liver, with intermediate values in adipose tissue and muscle (Yang et al, 2006; Isensee et al., 2007); many of these genes are implicated in common diseases in which susceptibility is sexbiased.”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “The flexibility of epigenetic marks makes it possible for all these above-mentioned influences to alter existing DNA methylation patterns, create new histone marks, or modify the chromatin structure during a particular spatiotemporal window, sometimes in a sex-specific manner (377, 426).”