Metallothionein: the multipurpose protein

By P. Coyle, J. Philcox, L. Carey, A. Rofe. Cellular and Molecular Life Sciences (CMLS), 2002

1,340 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/7d1af7fa1d6b8d2ef52b4282a70aa06d55f4c253

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In Health, Toxicology and Mutagenesis

In Hematology

In Nutrition and Dietetics

Citations in the corpus

Metallothionein 1 (CcMT1) of pigeonpea (Cajanus cajan, L.) confers enhanced tolerance to copper and cadmium in Escherichia coli and Arabidopsis thaliana (2011, background): “In yeast and animal systems, MTs were ound to play key role in the metal homeostatic mechanism (Ecker t al., 1989; Borrelly et al., 2002; Coyle et al., 2002).”
Canine models of copper toxicosis for understanding mammalian copper metabolism (2011, neutral): “2009) and is sequestered by small molecules like metallothionein (Coyle et al. 2002) and glutathione (Freedman et al.”
The Role of Metallothionein in Oxidative Stress (2013, background): “Metallothioneins (MTs) belong to the group of intracellular cysteine-rich, metal-binding proteins that have been found in bacteria, plants, invertebrates and vertebrates [12–14].”
Metallothionein-1G Facilitates Sorafenib Resistance through Inhibition of Ferroptosis (2016, background): “Metallothioneins (MTs) are low-molecular weight and cysteine-rich proteins that are highly induced in response to different environmental stressors including metal ions, cytokines, and free radicals.((6)) MTs play a critical role in heavy metal detoxification and antioxidants.”
Cellular Mechanisms in Higher Plants Governing Tolerance to Cadmium Toxicity (2014, background): “The role of MTs in Zn homeostasis and Cd detoxification in mammals has been intensively studied (e.g., Palmiter, 1998; Coyle et al., 2002).”
Interactive effects of metal pollution and temperature on metabolism in aquatic ectotherms: implications of global climate change (2008, background): “…different metals may vary, many metals have common toxic cellular mechanisms and elicit similar protective responses in a wide variety of organisms (reviewed by Byczkowski & Sorenson 1984, Roesijadi & Robinson 1994, Wallace & Starkov 2000, Coyle et al. 2002, Valko et al. 2005, Amiard et al. 2006).”
Copper, oxidative stress, and human health. (2005, background): “In addition to a role of glutathione in oxidant stress protection, glutathione can also chelate metals such as Zn and Cu and mediate the transfer of these metals between proteins such as metallothionein (Coyle et al., 2002; Freedman et al., 1989).”
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “These proteins play an important role in zinc uptake, distribution, storage and release, and are protective in situ ations of stress (exposure to oxyradicals), exposure to toxic metals, and low Zn nutrition [238,239].”
Zinc and human health: an update (2011, positive): “In this situation, MTs may both protect neurons from oxidative stress as well as modulate neurotransmission (Coyle et al. 2002; Stefanidou and Maravelias 2004).”
Comprehensive characterization of skeletal tissue growth anomalies of the finger coral Porites compressa (2006, positive): “Studies showing the interaction of zinc, metallothionein, and mitochondrial function further support the role of metallothionein as a regulator of cellular energy production and redox state (Maret 2000, 2003;Coyle et al. 2002).”
Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling (2017, background): “heavy metal detoxification, metal storage, and donation to target apometalloproteins (particularly to zinc finger proteins and newly synthesized apoenzymes) (Cousins 1985; Coyle et al. 2002; Kondoh et al. 2003).”
Review of health safety aspects of nanotechnologies in food production. (2009, background): “Also the metallic core of quantum dots (and other metal-oxides) could be bound by metallothionein and excreted via liver and kidney (Coyle et al., 2002).”