The neural correlates of anhedonia in major depressive disorder.

By P. Keedwell, C. Andrew, Steven C. R. Williams, M. Brammer, Mary L. Phillips. Biological Psychiatry, 2005

671 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/7ba3a5f12e99f4abbfd75682775bb92ae59407f7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Michael T. Treadway
2. David H. Zald
3. Diego A. Pizzagalli
4. Mercè Correa
5. John Salamone
6. Greg Hajcak
7. Dan Foti
8. Eddie Harmon-Jones

In Experimental and Cognitive Psychology

1. Diego A. Pizzagalli
2. Mercè Correa
3. John Salamone
4. Dan Foti
5. Michael T. Treadway
6. David H. Zald
7. Eddie Harmon-Jones
8. Andre Der-Avakian

In Pharmacology

1. Mercè Correa
2. John Salamone
3. Diego A. Pizzagalli
4. Michael T. Treadway
5. David H. Zald
6. Kent C. Berridge

Citations in the corpus

• Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits (2007, background): “Several studies have focused upon emotional stimuli; as was the case with the early animal literature, a common view has become that accumbens activity as measured in imaging studies is closely associated with pleasure (e.g., Peterson 2005; Keedwell et al. 2005; Sarchiapone et al. 2006).”
• The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques (2009, background): “These findings show that anhedonia predicts ventral striatal responses to rewarding stimuli not only in depressed patients (Epstein et al., 2006; Keedwell et al., 2005), but also in healthy subjects, and emphasize substantial specificity between reward-related NAcc responses and anhedonia.”
• Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study (2011, background): “In particular, a blunted VS response in depression is specifically correlated with anhedonia (Keedwell et al., 2005; Wacker et al., 2009) and deep brain stimulation of the VS attenuates anhedonic symptoms (Schlaepfer et al.”
• The Neurobiology of Anhedonia and Other Reward-Related Deficits (2011, background): “In humans, anhedonia severity, but not depression severity per se, negatively correlated with ventral striatal activity in response to pleasant stimuli [34, 35, 52], monetary rewards [37], and positive words [53].”
• Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model (2014, background): “Second, negative correlations between ventral striatal activation to positive cues and anhedonia have been reported (Epstein et al. 2006, Keedwell et al. 2005).”
• Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “…to subgenual and rostral regions during resting-state, passive affective stimulus viewing and cognitive control tasks (Drevets et al., 2002; Keedwell et al., 2005a, b; Wagner et al., 2008), while more dorsal regions ACC appear critical for costbenefit decision-making (Croxson et al., 2009;…”