Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

By Seong-Woon Yu, Hongmin Wang, Marc F. Poitras, C. Coombs, W. Bowers, H. Federoff, G. Poirier, T. Dawson, Valina L. Dawson. Science, 2002

1,899 citations recorded by the source corpus.

Subfields: Electrical and Electronic Engineering, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/7b6d94906866ab52104a903207582f2436ea697d

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Citations in the corpus

• Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures (2010, background): “; caspase-3 was not activated by glutamate exposure, nor was DNA fragmented (ref”
• On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. (2012, background): “PARP-1 activation in response to excessive DNA damage triggers the release of AIF from mitochondria and promotes PARP-1-dependent cell death or parthanatos (Fig. 5, highlight 6; Yu et al. 2002; David et al. 2009; Wang et al. 2011).”
• AIF deficiency compromises oxidative phosphorylation (2004, background): “Upon apoptosis induction, AIF translocates from mitochondria to the cytosol and to the nucleus (Susin et al, 1999; Yu et al, 2002 ).”
• XRCC1 and DNA strand break repair. (2003, background): “In addition, PARP-1 is also implicated in the induction of cell death [36,37].”
• Alkylating DNA damage stimulates a regulated form of necrotic cell death. (2004, background): “Some work has implicated PARP in the regulation of DNA repair and cell survival (Wang et al. 1997), whereas others have implicated PARP in initiating cell death by either apoptosis (Yu et al. 2002) or necrosis (Ha and Snyder 1999).”
• The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors (2002, background): “In addition to PARP-1, histones are also considered to be major acceptors of poly(ADP-ribose) (Tanuma et al., 1985; Nagele, 1 Abbreviations: PARP-1, poly(ADP-ribose) polymerase-1; A-T, ataxia telangiectasia; bNOS, brain nitric-oxide synthase; BRCT, breast cancer susceptibility protein C terminus; ca”
• Minocycline: far beyond an antibiotic (2013, background): “However, few data exist regarding minocycline’s ability to promote motor recovery after SCI, rendering this possibility controversial.”
• Mechanisms of cytochrome c release from mitochondria (2006, background): “However, in other models AIF is released before Cyt c.(18) In the presence of an heat-labile cytosolic factor, AIF can promote MOMP, as demonstrated in vitro by the release of Cyt c from purified mitochondria induced”
• The PARP superfamily (2004, background): “The treatment of fibroblasts or cortical neurons with very high doses of DNA-damaging agents such as MNNG, NMDA or H2O2, induces cell death through the translocation of AIF but the translocation is inhibited in the presence of PARP inhibitor 3,4-dihydro-5[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinon”