Mechanisms of cytochrome c release from mitochondria

By C. Garrido, L. Galluzzi, M. Brunet, P. Puig, C. Didelot, Guido Kroemer. Cell Death and Differentiation, 2006

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Silver nanoparticles: Synthesis, medical applications and biosafety (2020, background): “Superoxide radicals directed to mitochondria may enhance mitochondrial outer membrane permeabilization (MOMP) and the release of Cyt c, destroy the electron transport chain, and impair mitochondrial function [256].”
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation (2013, background): “Peroxidation of cardiolipin results in the release of bound cytochrome c into the cytosol where it binds to Apaf-1 (Garrido et al., 2006; Immunity 39, 1–13, August 22, 2013 ª2013 Elsevier Inc. 9 (legend continued on next page) Nlrp3 Inflammasome Activation through Cardiolipin 10 Immunity 39, 1–13, A”
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis (2008, background): “This protein is an irreplaceable component of the mitochondrial electron transport chain, shuttling electrons from complexes III to IV, and is thus essential to life: the disruption of its only gene is embryonic lethal (Garrido et al., 2006).”