Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells.

By R. Gastpar, M. Gehrmann, M. Bausero, A. Asea, C. Gross, J. Schroeder, Gabriele Multhoff. Cancer Research, 2005

683 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7b5421be50de611242d2f2c5f4ee2190e71aff1c

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Citations in the corpus

• Exosome Theranostics: Biology and Translational Medicine (2018, background): “Tumor-derived exosomes also stimulate NK cell activity; exosomes derived from pancreatic carcinoma cell sublines expressing HSP70 stimulate migration and lytic activity in NK cells against HSP70 surface-positive tumors (Figure 5G) [91].”
• Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, result): “In line with these findings, tumor-derived HSP70/Bag-4+ exosomes stimulate NK cell activity, inducing granzyme B release and pancreatic cancer cell apoptosis (Gastpar et al., 2005).”
• Membrane vesicles as conveyors of immune responses (2009, background): “For example, exosomes or membrane vesicles derived from heat-shocked tumour cells bear heat shock protein 70 (HSP70) on their surface and can promote NK cell activit”
• Exosome Function: From Tumor Immunology to Pathogen Biology (2008, background): “Interestingly, recent studies by Muntasell et al. showed that in a 24-h period, 12% of the surface-bound peptide–MHCII complex is endocytosed, 874 Traffic 2008; 9: 871–881 trafficked to MVBs and released on exosomes, suggesting that exosome discharge may be a common mechanism to seed secondary lymph”
• Exosomes in cancer development, metastasis, and immunity (2019, background): “HSP70 on the exosome surface also stimulated NK cell migration and cytolytic activity [117], macrophage activity [118] and induced stronger anticancer immune responses of helper T cells [119].”
• Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes (2012, background): “Exosomal Hsps are present on the surface of exosomes and can modulate immunological responses (16).”
• Cancer despite immunosurveillance: immunoselection and immunosubversion (2006, background): “Importantly, colon- and pancreatic-carcinoma cells can release HSP70-bearing exosomes that stimulate the cytolytic activity of NK cells against tumour”
• Exosomes and their roles in immune regulation and cancer. (2015, background): “In an effort o understand immune-related functions of exosomes, recent studes have investigated specific components of exosomes that directly r indirectly regulate the tumour immune response [11,29–31].”
• Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC (2015, background): “required for HSP70 accumulation,(31,32) with HSP70 having the ability to activate NK cell cytotoxicity,(33) and HSP70 surfacepositive exosomes reportedly favoring migratory and cytolytic activity of NK cells.(34) Although elevated soluble BAG6 in the serum of leukemic patients appears to correlate w”