A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy.

By Yanhua Tian, Suping Li, Jian Song, Tianjiao Ji, Motao Zhu, G. Anderson, Jingyan Wei, Guangjun Nie. Biomaterials, 2014

1,649 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7b28f4764f55c79d8d2be44f0973a676da9973a6

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In Materials Chemistry

In Molecular Biology

Citations in the corpus

Clinical applications of stem cell-derived exosomes (2024, methodology): “47 Kim et al. loaded paclitaxel in RAW 264.7-derived exosomes using incubation and sonication to overcome multidrug resistance in cancer cells.”
Engineering exosomes for targeted drug delivery (2021, methodology): “DOX iRGD peptide LAMP-2B breast cancer Targeted delivery of DOX [49]”
The biology, function, and biomedical applications of exosomes (2020, positive): “For example, av integrin-specific RGD (R, arginine; G, glycine; D, aspartic acid)–modified peptide (amodified tumor-homing peptide sequence that acts as a recognition sequence for integrins) on immature dendritic cell–derived exosomes loaded with doxorubicin showed therapeutic response inmammary tum”
Exosome Theranostics: Biology and Translational Medicine (2018, background): “For instance, exosomes were engineered to express targeting ligands, such as iRGD-Lamp2b, to enhance tumor-specific uptake; the intravenous injection of these exosomes obviously suppressed tumor growth [183].”
Advances in therapeutic applications of extracellular vesicles (2019, background): “Another publication demonstrated increased tumor targeting and antitumor effects by engineered EVs loaded exogenously with doxorubicin (126).”
Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications (2020, neutral): “The exosome delivery system has various routes of administration, among which the common routes include intravenous injection, 118,119 subcutaneous injection, 120 intraperitoneal injection, 121,122 intratumoral injection, 123 nasal administration 32,105,124,125 and oral administration.”
Biodistribution and Delivery Efficiency of Unmodified Tumor-Derived Exosomes (2014, background): “Regardless, our results demonstrate the rapid uptake of exosomes by the liver and spleen, consistent with previous reports examining the biodistribution of exosomes [20, 22, 23].”
Exosomes as Drug Delivery Vehicles for Parkinson’s Disease Therapy (2015, background): “In this respect, several reports indicated that exosomes may have an immune privileged status that can efficiently decrease drug clearance [20-22].”
Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “Thus, low molecular antioxidant, curcumin [89,90], anticancer agents, Doxorubicin (Dox) [92,93] and Paclitaxel (PTX) [94], and a model drug Rhoda-mine 123 [94] were loaded into exosomes or exosome-like vesicles by incubation at room temperature (RT).”