Rapid leukocyte migration by integrin-independent flowing and squeezing

By T. Lämmermann, B. Bader, S. Monkley, T. Worbs, R. Wedlich-Söldner, Karin Hirsch, M. Keller, R. Förster, D. Critchley, R. Fässler and 1 more. Nature, 2008

1,408 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/7ae019be228b9d856d65c7fc552b264b8589d1bb

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Citations in the corpus

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited (2009, neutral): “4 A) (Huber and Weiss, 1989; Mandeville et al., 1997; Wolf et al., 2003b; Lammermann et al., 2008).”
Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells. (2015, neutral): “This is reminiscent of the behavior of leukocytes, such as dendritic cells, which are known to migrate fast and independently of specific integrin-based adhesion (Lämmermann et al., 2008; Lämmermann and Sixt, 2009; Hawkins et al., 2009; Heuzé et al., 2013).”
Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “Blebbing has also been shown to be an important mode of motility in vivo during development, in specialized moving cells like leukocytes and possibly in other three-dimensional motility contexts such as cancer cell invasion (29, 168, 169).”
DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. (2020, background): “Indeed, neutrophils tend to migrate in an exponentially clustered fashion through the interstitial space, a process also referred to as neutrophil swarming (63, 65, 66).”
Development and function of dendritic cell subsets. (2014, neutral): “Integrins, on the other hand, are dispensable for themigration of cDCs to LNs under physiological conditions (Lämmermann et al., 2008) but are needed for optimal migration during contact sensitization (Johnson et al.”
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “The ameboid migration of isolated cancer cells through interstitial matrices may proceed independently of β1 integrins as demonstrated for leukocytes (Lammermann et al., 2008).”
Extracellular matrix: a dynamic niche component during cancer progression (2012, neutral): “3 B, stage a; Lämmermann et al., 2008).”
Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, neutral): “Recent studies identified two unexpected examples for alternative migration modes in 3D environments: the interstitial migration of leukocytes independently of integrin (Friedl and Weigelin, 2008; Lämmermann et al., 2008; Lämmermann and Sixt, 2009) and the propulsive cell migration of normal and neo”
The lymphatic vasculature in disease (2011, background): “Interestingly, because the lymphatic basement membrane has preformed holes and the lymphatic endothelium has flaps, lymphatic entry of DCs may not require proteolysis or integrin”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “, high shear flow) bloodstream, this migration may not be dependent on integrins, given that subcutaneously injected pan-integrin-deficient DCs are able to migrate normally into the draining LN (51).”