Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells.

By Yan-Jun Liu, M. Le Berre, F. Lautenschlaeger, P. Maiuri, A. Callan-Jones, Mélina L. Heuzé, T. Takaki, Raphael Voituriez, M. Piel. Cell, 2015

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Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves (2015, background): “…along the blood vessel showed that the interactions occurred between blebs and protrusions emanating from both cell types, providing a discontinuous surface that could potentially generate traction for movement (Figure 3G; Movie S2) (Bergert et al., 2015; Liu et al., 2015; Tozluo glu et al., 2013).”
The Actin Cytoskeleton and Actin-Based Motility (2018, background): “An amoeboid mode of cell migration, especially when cells move in a spatially constrained environment, involves extensive blebbing (Liu et al. 2015; Ruprecht et al. 2015).”
Modelling fluid deformable surfaces with an emphasis on biological interfaces (2018, background): “Adhesion-independent locomotion plays a major role in three-dimensional cell migration through the extracellular matrix or in confined environments (Poincloux et al. 2011; Liu et al. 2015).”