The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.

By Y. Date, N. Murakami, K. Toshinai, S. Matsukura, A. Niijima, H. Matsuo, K. Kangawa, M. Nakazato. Gastroenterology, 2002

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Ghrelin: structure and function. (2005, background): “Peripherally injected ghrelin stimulates hypothalamic neurons (104, 201, 258) and stimulates food intake (56, 265).”
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. (2004, background): “In addition, ghrelin is thought to be produced in brain centers of energy balance control, and, although present there in very small amounts, brain-derived ghrelin might play an additional role in the regulation of energy homoeostasis (51, 123, 152, 198, 372).”
Anatomy and regulation of the central melanocortin system (2005, background): “Furthermore, surgical or chemical vagotomy blocks stimulation of feeding and c-Fos activation in the arcuate nucleus after peripheral but not central administration of ghreli”
Gut hormones and the regulation of energy homeostasis (2006, background): “Vagotomy has been reported to block or attenuate the orexigenic effects of ghreli”
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. (2004, background): “(16) have shown that vagotomy blocks the orexigenic activity of circulating ghrelin, indicating that ghrelin signaling may reach the arcuate nucleus by route of vagal afferents.”