Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.
By Suzanne M. Mandala, R. Thornton, Zhenxing Tu, M. Kurtz, J. Nickels, James R. Broach, R. Menzeleev, Sarah Spiegel. 1998
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Citations in the corpus
- Mammalian Ceramide Synthases (2010, background): “The opposing functions that ceramide and S1P play in signaling pathways suggests that this mode of regulation might be of significance in cell physiology, and may provide a molecular explanation for the so-called ceramide/S1P rheostat (53), which proposes that the balance between S1P and ceramide de”
- Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. (2001, background): “Until now, it was claimed that only the sphingoid bases and their phosphorylated counterparts are required for the full heat shock response in yeast (Mandala et al., 1998; Skrzypek et al., 1999).”
- Lip1p: a novel subunit of acyl‐CoA ceramide synthase (2005, unknown): “The term ‘sphingolipid rheostat’ has been used to describe this critical balance (Cuvillier et al, 1996; Mandala et al, 1998; Maceyka et al, 2002; Kobayashi and Nagiec, 2003).”
- An overview of sphingolipid metabolism: from synthesis to breakdown (2010, background): “More recently, SPP2 was shown to be upregulated during inflammatory responses, however, it is unclear what effect this has on sphingolipid metabolism [152].”
- Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network (2005, background): “Coordinated activities of biosynthetic and biodegradative enzymes stringently maintain the concentrations of each of these lysophospholipids in the ranges that are required for optimal physiological activitie”