Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

By Y. Fujio, Thao Nguyen, D. Wencker, R. Kitsis, K. Walsh. Circulation, 2000

882 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/7aac15a89477d66d7c663e587a8e2042fc9d3900

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Yellon
2. D. Hausenloy
3. K. Walsh
4. Susan A. Elmore
5. E. Murphy
6. C. Steenbergen
7. M. Mocanu

In Pathology and Forensic Medicine

1. D. Yellon
2. D. Hausenloy
3. G. Heusch
4. E. Murphy
5. C. Steenbergen
6. S. Cadenas
7. M. Mocanu

Citations in the corpus

• Apoptosis: A Review of Programmed Cell Death (2007, background): “Infusion of insulin-like growth factor-1 (IGF1), which stimulates PKB/Akt signaling and promotes cell survival, was shown to be beneficial in animal models of myocardial ischemia (Fujio et al., 2000).”
• New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. (2004, background): “Signalling through PI3 kinase has been demonstrated to confer protection against ischaemia–reperfusion injury [27,28], through its activation of the serine– threonine kinase, Akt [29].”
• Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. (2005, neutral): “(57) and were stained with H&E for overall morphology, Masson’s tri-”
• Targeting PI3K/Akt signal transduction for cancer therapy (2021, background): “TLRs can identify conserved microbial motifs in bacterial lipopolysaccharides (recognized by TLR4) and single- or double-stranded RNA (identified by TLR3).(57) TLRs also distinguish and bind endogenous ligands, thereby activating the signaling pathway.”
• HMG-CoA reductase inhibitor mobilizes bone marrow--derived endothelial progenitor cells. (2001, background): “Constitutive activation of Akt signaling also protects cardiomyocytes from apoptosis after ischemia-reperfusion injury in vivo (38).”
• Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms (2005, methodology): “We qualitatively analyzed myocardial apoptosis by TUNEL staining as previously describe”