ERM proteins and merlin: integrators at the cell cortex

By A. Bretscher, K. Edwards, R. Fehon. Nature reviews. Molecular cell biology, 2002

1,418 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7a5005812fc5593f99be73134ec24d548f27d161

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

Citations in the corpus

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis (2003, background): “ROCK also phosphorylates the ezrin/radixin/moesin-family proteins that link the actin cytoskeleton to the plasma membran”
GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition (2008, background): “ERM proteins exist in an inactive conformation and are activated by phosphatidylinositol-4,5-bisphosphate binding and subsequent phosphorylation of the carboxyl terminus (for a review, see Ref”
The Hippo signalling pathway and its implications in human health and diseases (2022, background): “61 Mer/NF2 contributes to the recruitment of Hippo kinase and participates in the activation of the Hippo pathway.”
Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “Various proteins involved in this linkage have been identified, among which proteins from the ERM (ezrin, radixin, moesin) family are one of the most important players (41, 56, 192).”
ICAM-1 signaling in endothelial cells (2009, background): “The mechanism by which ICAM-1 activates Rho is not known, but the involvement of ERMproteins and Rho-GDI in sustaining Rho activation has been suggested [7].”
The Hippo pathway: regulators and regulations. (2013, background): “Mer and Ex have been considered as a linker for the apical plasma membrane and actin cytoskeleton (Bretscher et al. 2002).”
The extracellular matrix guides the orientation of the cell division axis (2005, background): “, which links the plasma membrane with cortical acti”
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis (2006, background): “and is thought to transduce a signal from membrane receptors to intracellular downstream component”
The role of the Rho GTPases in neuronal development. (2005, background): “Moesin is an ERM family protein that has been proposed to link membrane to the actin cytoskeleton (Bretscher et al. 2002), and Rho-kinase has been reported to phosphorylate and thus activate moesin (Jeon et al. 2002).”
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis (2004, background): “1 superfamily of proteins, ezrin is the best-characterized ERM (ezrin-radixin-moesin) protei”