The extracellular matrix guides the orientation of the cell division axis

By Manuel Théry, V. Racine, A. Pépin, M. Piel, Yong Chen, Jean-Baptiste Sibarita, M. Bornens. Nature Cell Biology, 2005

826 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/1d52b9521a1a4623cbf17c3d4c97412abac874ac

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Manuel Théry
2. T. Mammoto
3. Peter K. Sorger
4. Donald E. Ingber
5. D. Pellman
6. Carmel Majidi
7. P. Janmey
8. Kenneth M. Yamada

In Immunology and Allergy

1. Donald E. Ingber
2. Manuel Théry
3. T. Mammoto

Citations in the corpus

• Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression (2015, background): “For instance, upon fertilization of the egg, the orientation of the spindle axis, and thus the orientation of cell divisions, is governed by the spatial distribution of ECM adhesions and thus cytoskeletal tension imposed upon the cells.(23) In developing Xenopus embryos, a temporal and spatial distr”
• Patterning surfaces with functional polymers. (2008, background): “The applications of polymer-patterned surfaces can be tentatively organized into several categories: (1) the fabrication of light-emitting displays (LEDs), semiconductor microelectronics and plastic electronics1–3; (2) bio-related and medicinal research including the study of cells and tissue engine”
• Cells on chips (2006, background): “By allowing cells to spread and proliferate on these adhesive patches the orientation of the cell division axis can be controlle”
• Hydrodynamic stretching of single cells for large population mechanical phenotyping (2012, methodology): “We treated HeLa and NIH 3T3 fibroblasts with pharmacological inhibitors of two cytoskeletal components with roles in regulation of cell shape and motility, a compound shown to reorganize keratin intermediate filament networks, as well as an inhibitor of myosin contractility (blebbistatin) and charac”
• Micropatterning as a tool to decipher cell morphogenesis and functions (2010, background): “By changing the shape of a micropattern to manipulate cell adhesion and the associated location of cortical cues, it was shown that these cues are instrumental in guiding the orientation of the mitotic spindle (Théry et al., 2005).”
• Mechanical control of tissue and organ development (2010, background): “By culturing cells on microengineered adhesive substrates (see Box 2), researchers have confirmed that the orientation of the spindle axis and of cell divisions is governed by the spatial distribution of ECM adhesions that resist cell traction forces, and not by chemical signals generated in respons”
• Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. (2008, methodology): “The interphase adhesion pattern and the distribution of actin-containing RFs are known to strongly influence spindle orientation during mitosis (Thery et al. 2005).”