The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

By Fisun Hamaratoglu, M. Willecke, Madhuri Kango-Singh, R. Nolo, Eric Hyun, Chunyao Tao, Hamed Jafar-Nejad, G. Halder. Nature Cell Biology, 2006

780 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/33e7ec67baf6627feb5cf0d16810ae8e520a2772

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. K. Guan
2. Bin Zhao
3. G. Halder
4. Fa-Xing Yu
5. S. Piccolo
6. Duojia Pan
7. Randy L. Johnson
8. M. Cordenonsi

In Cellular and Molecular Neuroscience

1. Duojia Pan

In Molecular Biology

1. K. Guan
2. Duojia Pan
3. Bin Zhao
4. G. Halder
5. Randy L. Johnson
6. Fa-Xing Yu
7. S. Piccolo
8. M. Cordenonsi

Citations in the corpus

• Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. (2006, background): “This pathway also includes the genes salvador (sav), mob as tumor suppressor (mats), NF2/Merlin, and expanded (Hamaratoglu et al., 2006; Edgar, 2006) and functions to precisely control tissue expansion by coordinately regulating cell proliferation and cell death.”
• Metabolic control of YAP and TAZ by the mevalonate pathway (2014, background): “promotes LATSs activation by inducing their plasma membrane localization (Hamaratoglu et al., 2006).”
• Hippo signaling in organ size control. (2007, background): “An alternative model, which is compatible with the data presented by Hamaratoglu et al. (2006) although not considered by the authors, is that Mer and Ex might regulate Hpo indirectly by controlling the abundance of an upstream component of the Hpo pathway, such as its putative receptor.”
• Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. (2012, background): “Finally, the efficacy of TEAD2-DN and VP in suppressing Nf2-deficient phenotypes lends further support for a functional link between NF2/Merlin and Hippo signaling (Hamaratoglu et al. 2006; Zhang et al. 2010) and offers the promise of YAP inhibitors as molecular targeted therapeutics for NF2, a gene”
• TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway (2008, background): “For example, Mst and Lats are human homologues of the Drosophila Hpo and Wts, respectively (7).”
• The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. (2008, background): “…the expression of a handful of target genes, such as the cell cycle regulator cyclin E (cycE), the cell death inhibitor diap1, and the microRNA bantam (Thompson and Cohen, 2006; Nolo et al., 2006), as well as ex and mer, as part of a negative feedback regulatory loop (Hamaratoglu et al., 2006).”
• The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “In Drosophila, Yorkie is required for proliferation of several embryonic tissues, and loss of Hippo pathway components or F-actin inhibitors induces tissue overgrowth (57, 77, 81, 97, 129, 181, 201).”
• The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals (2010, background): “…have implicated the apical membrane-associated FERM-domain proteinsMerlin (Mer) and Expanded (Ex) as pathway components upstream of Hpo (Maitra et al., 2006; Hamaratoglu et al., 2006; Pellock et al., 2007; Tyler and Baker, 2007), although how Mer and Ex regulate Hpo activity was not established.”
• Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, positive): “Merlin (Mer), Expanded (Ex), and Kibra, three cell-cortex-localized and cytoskeleton-interacting proteins, may function as a scaffold for core Hippo components at the apical domain for activation, as Sav, Hpo, and Wts have been shown to physically interact with Ex/Mer/Kibra (Baumgartner et al., 2010”
• Hippo pathway regulation by cell morphology and stress fibers (2011, background): “The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.”
• The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal (2011, neutral): “Two apical cytoskeleton-binding proteins, Merlin (Mer) and Expanded (Ex”