Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

By A. Clement, Minh N. H. Nguyen, E. A. Roberts, M. L. Garcia, S. Boillée, M. Rule, Andrew P. McMahon, Wilder T. Doucette, D. Siwek, R. Ferrante and 5 more. Science, 2003

1,126 citations recorded by the source corpus.

Subfields: Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/7a480fc1382cc0616e016efbff627f88eaaf29f7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Robert H. Brown
2. Fred H. Gage
3. Christopher K. Glass
4. P. Pasinelli
5. R. Ransohoff
6. Berislav Zlokovic

In Neurology

1. R. Ransohoff
2. M. Sofroniew
3. Christopher K. Glass
4. Kaoru Saijo
5. V. Perry
6. Andrea Volterra
7. Robert H. Brown
8. J. Herrmann

Citations in the corpus

• Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF (2006, background): “The mechanism through which mutant SOD1 triggers disease seems to involve pathogenic processes in the local environment of motoneuron”
• Microglial physiology: unique stimuli, specialized responses. (2009, background): “Transgenic mice expressing the mutant SOD-1 have been a valuable model for understanding disease pathogenesis, revealing that the demise of the motorneurons is not a cell-autonomous event, but rather depends on the surrounding non-neuronal cells (131).”
• Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury (2004, background): “Normal glia protect spinal cord motor neurons from degeneration in a mutant mouse model of amyotrophic lateral sclerosis (Clement et al., 2003).”
• Mitochondria in health and disease: perspectives on a new mitochondrial biology. (2004, neutral): “This view is supported by the remarkable observation that in chimeric mice with cells expressing either normal and mutant SOD1, toxicity to MNs seemed dependent on damage from the SOD1 and mutation expressed in nonneuronal cells (Clement et al., 2003).”
• Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons (2007, background): “Expression of mutated SOD1 in both motor neurons and non-neuronal cells has been suggested as contributing to the disease process in vivo”
• Molecular biology of amyotrophic lateral sclerosis: insights from genetics (2006, result): “Analyses of chimeric mice with mixed populations of cells expressing either endogenous or transgenic mutant SOD1 were consistent with this vie”
• Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis (2014, positive): “Elegant studies using these animals have shown that nonneuronal cells play a crucial role in ALS, contributing to MN death via non-cell-autonomous mechanisms (Clement et al., 2003).”