Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation

By S. Epelman, Kory J. Lavine, Anna E. Beaudin, Dorothy K. Sojka, Javier A. Carrero, B. Calderon, Thaddeus Brija, E. Gautier, Stoyan Ivanov, Ansuman T. Satpathy and 10 more. Immunity, 2014

1,364 citations recorded by the source corpus.

Summary Cardiac macrophages are crucial for tissue repair after cardiac injury but have not been well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6chi monocytes contributed to all four macrophage populations, whereas resident macrophages also expanded numerically through proliferation. Genetic fate mapping revealed that yolk-sac and fetal monocyte progenitors gave rise to the majority of cardiac macrophages, and the heart was among a minority of organs in which substantial numbers of yolk-sac macrophages persisted in adulthood. CCR2 expression and dependence distinguished cardiac macrophages of adult monocyte versus embryonic origin. Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis. These data highlight the presence of multiple cardiac macrophage subsets, with different functions, origins and strategies to regulate compartment.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/a79a62e62f403234bbd1523e9131235a0083d081

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Douglas L. Mann
2. Sumanth D. Prabhu
3. Nikolaos G. Frangogiannis

In Molecular Biology

1. Douglas L. Mann
2. S. Gordon
3. A. Mildner
4. Steffen Jung
5. C. Varol
6. D. Ornitz
7. Tamás Rőszer
8. P. Italiani

In Surgery

1. S. Gordon
2. C. Nichols

Citations in the corpus

• Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms (2015, background): “However, it is shown that the resident tissue macrophages have heterogeneous progeny [187, 188].”
• Macrophages Facilitate Electrical Conduction in the Heart (2017, neutral): “Macrophages are an intrinsic part of the healthy working myocardium, where they appear as spindle-like cells interspersed among myocytes, fibroblasts and endothelial cells (Pinto et al., 2012; Heidt et al., 2014; Epelman et al., 2014).”